Regulation of fetoplacental vascular bed by hypoxia

Hampl, Václav; Jakoubek, V.

doi:10.33549/physiolres.931922

Cited by 33 publications

(3 citation statements)

References 30 publications

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“…Recent advancement in ultrasound technology has enhanced the study of morphometric variation of the umbilical cord vessels association with foetal outcome at birth [7]. For instance, evaluation of umbilical cord artery impedance to blood flow helps in identifying foetuses vulnerable to growth and developmental disorders [8].…”

Section: Discussionmentioning

confidence: 99%

Morphometric Characterization of Umbilical Cord Vessels and Neonatal Outcome

Bimpong¹,

Abaidoo²,

Atuahene³

et al. 2019

IJAR

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Morphologic and morphometric characterization of the umbilical cord and vessel components could greatly assist in improving adverse maternal and neonatal outcomes. The aim of this study was to evaluate the relationship between morphometry of umbilical cord vessel components and neonatal outcome. A descriptive cross sectional study was conducted on 207 umbilical cords attached to placentae obtained from Victory Maternity Home and Clinic in Kumasi (Ghana) between November, 2013 and October, 2014. Umbilical cord length, diameter, and vessels' diameter were measured with the umbilical cord still attached to the placenta. Neonatal anthropometries were recorded within 24 hours after delivery. The mean ± SD of vein diameter between neonates of normotensive 3.36 (±0.88) and hypertensive mothers 3.82 (± 0.50) showed a significant difference. The body length of neonates with short umbilical cord length was significantly lower (p < 0.05) than that of those with long cord lengths. Quantitative analysis indicated a positive linear relationship in umbilical cord and its vessels components with neonatal anthropometry (p<0.05). In conclusion, the morphometry of the umbilical cord and its vessels could predict maternal and neonatal outcome and therefore would be useful in early detection and management of neonatal abnormalities.

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Section: Discussionmentioning

confidence: 99%

Morphometric Characterization of Umbilical Cord Vessels and Neonatal Outcome

Bimpong¹,

Abaidoo²,

Atuahene³

et al. 2019

IJAR

View full text Add to dashboard Cite

show abstract

“…Nonetheless, several data concerning endothelial function comes from HUVEC-based studies (M. R. Richardson et al, 2010), providing mechanisms that may not occur in all EC types. In this regard, further studies focus on chorionic and umbilical arteries are required to enhance the understanding of the placental vascular function and dysfunction, especially considering their specific responses to oxygen (Hampl & Jakoubek, 2009), shear stress (Hoffmann et al, 2003;Learmont & Poston, 1996;Saw et al, 2018), and oxidative stress (Proietti et al, 2016). Moreover, there are significant differences within the arterial vascular bed in the placenta, especially those related to the vasoconstriction to diverse oxygen levels (Hampl & Jakoubek, 2009;Leung et al, 2006;Tiritilli, 2000).…”

Section: Nitric Oxide Regulating Placental Vascular Functionmentioning

confidence: 99%

Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy

Krause

2021

Journal Cellular Physiology

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More than 30 years have passed since endothelial nitric oxide synthesis was described using the umbilical artery and vein endothelium. That seminal report set the cornerstone for unveiling the molecular aspects of endothelial function. In parallel, the understanding of placental physiology has gained growing interest, due to its crucial role in intrauterine development, with considerable long-term health consequences. This review discusses the evidence for nitric oxide (NO) as a critical player of placental development and function, with a special focus on endothelial nitric oxide synthase (eNOS) vascular effects. Also, the regulation of eNOSdependent vascular responses in normal pregnancy and pregnancy-related diseases and their impact on prenatal and postnatal vascular health are discussed. Recent and compelling evidence has reinforced that eNOS regulation results from a complex network of processes, with novel data concerning mechanisms such as mechano-sensing, epigenetic, posttranslational modifications, and the expression of NO-and L-arginine-related pathways. In this regard, most of these mechanisms are expressed in an arterial-venous-specific manner and reflect traits of the fetal systemic circulation. Several studies using umbilical endothelial cells are not aimed to understand placental function but general endothelial function, reinforcing the influence of the placenta on general knowledge in physiology.

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“…This decrease in vascular resistance does not occur in intrauterine growth restriction (also known as fetal growth restriction) pregnancies in which the unborn baby does not grow at the expected rate inside the womb (Kingdom and Kaufmann, 1997;Chaddha et al, 2004). It has been commonly assumed that this pathological condition arises from hypoxia-induced vasoconstriction of the fetoplacental vessels, resulting in placental hypoperfusion and consequently fetal malnutrition (Hampl and Jakoubek, 2009). Hypoxic fetoplacental vasoconstriction is induced by the hypoxic inhibition of oxygen-sensitive Kv channels, as indicated by mimicry of the hypoxia-induced down-regulation of I K in in vitro-perfused placental cotyledons, which are placental lobules consisting of a mass of chorionic villi, by the application of the Kv channel blocker 4-aminopyridine (4-AP; Hampl et al, 2002).…”

Section: Placentamentioning

confidence: 99%

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

Bocksteins

2016

Journal of General Physiology

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Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not form functional homotetrameric channels but assemble with Kv2 subunits into heterotetrameric Kv2/KvS channels with unique biophysical properties. Unlike the ubiquitously expressed Kv2 subunits, KvS subunits show a more restricted expression. This raises the possibility that Kv2/KvS heterotetramers have tissue-specific functions, making them potential targets for the development of novel therapeutic strategies. Here, I provide an overview of the expression of KvS subunits in different tissues and discuss their proposed role in various physiological and pathophysiological processes. This overview demonstrates the importance of KvS subunits and Kv2/KvS heterotetramers in vivo and the importance of considering KvS subunits and Kv2/KvS heterotetramers in the development of novel treatments.

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Regulation of fetoplacental vascular bed by hypoxia

Cited by 33 publications

References 30 publications

Morphometric Characterization of Umbilical Cord Vessels and Neonatal Outcome

Morphometric Characterization of Umbilical Cord Vessels and Neonatal Outcome

Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

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