2023
DOI: 10.3389/fendo.2023.1183151
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Regulation of FGF2-induced proliferation by inhibitory GPCR in normal pituitary cells

Abstract: IntroductionIntracellular communication is essential for the maintenance of the anterior pituitary gland plasticity. The aim of this study was to evaluate whether GPCR-Gαi modulates basic fibroblast growth factor (FGF2)-induced proliferative activity in normal pituitary cell populations.MethodsAnterior pituitary primary cell cultures from Wistar female rats were treated with FGF2 (10ng/mL) or somatostatin analog (SSTa, 100nM) alone or co-incubated with or without the inhibitors of GPCR-Gαi, pertussis toxin (PT… Show more

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