Regulation of flowering time by FVE, a retinoblastoma-associated protein

Ausín, Israel; Alonso‐Blanco, Carlos; Jarillo, José A.; Ruiz-Garcı́a, Leonor; Martı́nez-Zapater, José M.

doi:10.1038/ng1295

Cited by 363 publications

(337 citation statements)

References 32 publications

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“…After exposure to vernalization, the sdr6 plants flowered earlier than the plants grown in LD and SD (Figure 4). This responsiveness of the sdr6 plants to GA and vernalization were similar to previous results for several autonomous pathway mutants (Ausin et al 2004;Henderson et al 2005;Mockler et al 2004). In addition, transcript levels of critical genes in the autonomous pathway, i.e., FLC, LD, FVE, and SOC1 were significantly altered in sdr6 plants.…”

Section: Discussionsupporting

confidence: 78%

SDR6 is involved in regulation of flowering time in Arabidopsis thaliana

Xing

Zhang

Yang

et al. 2014

Plant Biotechnology

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Identification of flowering-time related genes in Arabidopsis thaliana has very important and meaningful to understand the regulation mechanism of the flowering-time. One late flowering mutant plant which displays a delayed transition to flowering was obtained from the Arabidopsis T-DNA insertion mutant library. SDR6, which encodes a short-chain dehydrogenase/reductase containing a NAD(P)-binding domain in Arabidopsis, has been identified as a novel flowering-time gene in Arabidopsis by further analyzing of SDR6 complementing plants. The sdr6 plants displayed later flowering than wild-type plants both in long and short days, but flowered later in short day than in long day. The flowering-time of SDR6 complementing plants is similar to that of wild-type plants. The late-flowering phenotype of sdr6 plants was reversed by gibberellin and vernalization treatments, which is similar to those of several mutants in the autonomous pathway. Compared with the wild-type, expression levels of FLC, LD, FVE, and SOC1 genes, key components of the autonomous pathway, were significantly altered in sdr6 mutants. However, expression levels of the key genes in the photoperiod, gibberellin, and vernalization pathways were not obviously different. Therefore, this gene may be involved in the autonomous flowering pathway to regulate the Arabidopsis flowering.

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Section: Discussionsupporting

confidence: 78%

SDR6 is involved in regulation of flowering time in Arabidopsis thaliana

Xing

Zhang

Yang

et al. 2014

Plant Biotechnology

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“…fve-1, however, contains an Ala-to-Val missense mutation that may not represent a total loss of function. That fve-1 is not a null allele is supported by the fact that another missense mutation in Ler, fve-2, has a stronger late-flowering phenotype than fve-1 (Ausin et al, 2004). Thus, it is possible that if an fpa fve double mutant were constructed in the Ler genetic background using a null allele of fve, the double mutant may have pleiotropic phenotypes similar to those seen in the Col background.…”

Section: Discussionmentioning

confidence: 92%

“…Another cause for the differences in phenotypes are the alleles of fpa and fve used: fpa-7 and fve-4 (this study) and fpa-1 and fve-1 (Koornneef et al, 1998). fpa-1, fpa-7, and fve-4 likely represent null alleles; fpa-1 and fve-4 contain premature stop codons Ausin et al, 2004); and fpa-7 contains a T-DNA insertion (Michaels and Amasino, 2001). fve-1, however, contains an Ala-to-Val missense mutation that may not represent a total loss of function.…”

Section: Discussionmentioning

confidence: 99%

“…FVE and FLOWERING LOCUS D (FLD) have human homologs that coimmunoprecipitate with the histone deacetylase complex . FVE contains six WD repeats and is similar to mammalian retinoblastoma-associated proteins that are present in complexes involved in chromatin assembly and modification (Ausin et al, 2004;Kim et al, 2004). FLD encodes a protein that is homologous with the human protein LYSINE-SPECIFIC DEMETHYLASE1 (LSD1) that has been shown to act as a histone demethylase (Shi et al, 2004).…”

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Functional Redundancy and New Roles for Genes of the Autonomous Floral-Promotion Pathway

Veley

Michaels

2008

Plant Physiology

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The early-flowering habit of rapid-cycling accessions of Arabidopsis (Arabidopsis thaliana) is, in part, due to the genes of the autonomous floral-promotion pathway (AP). The AP promotes flowering by repressing expression of the floral inhibitor FLOWERING LOCUS C (FLC). AP mutants are therefore late flowering due to elevated levels of FLC, and this late-flowering phenotype is eliminated by loss-of-function mutations in FLC. To further investigate the role of the AP, we created a series of double mutants. In contrast to the phenotypes of single mutants, which are largely limited to delayed flowering, a subset of AP double mutants show a range of defects in growth and development. These phenotypes include reduced size, chlorophyll content, growth rate, and fertility. Unlike the effects of the AP on flowering time, these phenotypes are FLC independent. Recent work has also shown that two AP genes, FCA and FPA, are required for the repression and, in some cases, proper DNA methylation of two transposons. We show that similar effects are seen for all AP genes tested. Microarray analysis of gene expression in AP single and double mutants, however, suggests that the AP is not likely to play a broad role in the repression of gene expression through DNA methylation: very few of the genes that have been reported to be up-regulated in DNA methylation mutants are misexpressed in AP mutants. Together, these data indicate that the genes of the AP play important and sometimes functionally redundant roles in aspects of development in addition to flowering time.A fundamental question in biology is how differentiating cells make decisions between alternative fates. The change from vegetative to reproductive development in Arabidopsis (Arabidopsis thaliana) is an attractive model for studying the factors that regulate such developmental transitions. Early in the life cycle, the undifferentiated stem cells of the shoot apical meristem give rise to organ primordia that will produce the vegetative portions of the plant (e.g. leaves). Later, the shoot apical meristem switches to producing primordia that will form the reproductive organs (e.g. flowers). Proper timing of this transition is critical for successful reproduction. Therefore, plants have evolved mechanisms to regulate flowering in response to both endogenous and environmental factors (Boss et al., 2004). These mechanisms help to ensure that plants flower at a suitable time in their development and a favorable time of year.

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“…FVE was isolated by positional cloning 17 . Linkage analysis confirmed that acg1 might be fve, an allele of FVE (Fig.…”

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confidence: 99%