Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition

Liu, Na; Wu, Wei-Long; Wan, Xiao-Rui; Wang, Jing; Huang, Jia-Ni; Jiang, Yi-Yue; Sheng, Yi-Chao; Wu, Jun-Chao; Liang, Zhong-Qin; Qin, Zheng-Hong; Wang, Yan

doi:10.1016/j.redox.2024.103176

Cited by 7 publications

(1 citation statement)

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“…These findings suggest that NADPH not only is central to the cellular redox balance but also plays a critical role in regulating ferroptosis, potentially by influencing iron metabolism and lipid peroxidation ( 101 ). Understanding the nuances of the role of NADPH in these processes could provide novel perspectives on the modulation of ferroptosis and its implications in various pathophysiological conditions.…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Characteristics Of Ferroptosismentioning

confidence: 99%