Regulation of fungal ribonucleotide reductase by unusual dinucleotides

Lewis, William H.; McNaughton, David R.; LéJohn, Herb B.; Wright, Jim A.

doi:10.1016/0006-291x(76)90258-8

Cited by 22 publications

(5 citation statements)

References 15 publications

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“…The decline of CDP reductase activity confined to the latter part of S-phase might be due to either a rapid enzyme degradation or appearance of enzyme inhibitor(s). Such inhibitors have recently been demonstrated by Lewis et al (32). They have isolated from the water mould Achlya, phosphorylated dinucleosides which inhibit fungal as well as mammalian CDP reductase activity in vitro.…”

Section: Discussionmentioning

confidence: 93%

Cytidine 5′-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

Tyrsted¹,

Gamulin²

1979

Nucl Acids Res

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The optimal conditions and the effect of deoxyribonucleoside triphosphates were determined for CDP reductase activity in PHA-stimulated lymphocytes. The enzymatic reaction showed an absolute requirement for ATP. In the absence of ATP, only dATP showed a minor stimulation of the reduction of CDP to dCDP. During transformation the CDP reductase activity reached a maximum at the same time as the four deoxyribonucleoside triphosphate pools, corresponding to mid S-phase at about 50 h after PHA addition. The DNA polymerase activity reached a maximum at 57 h.

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Section: Discussionmentioning

confidence: 93%

Cytidine 5′-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

Tyrsted¹,

Gamulin²

1979

Nucl Acids Res

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“…However, a cause-and-effect relationship is difficult to establish. In further studies, Lewis et al (49,50) show that HS-3 inhibits ribonucleoside-diphosphate reductase (EC 1.17.4.1) significantly (50 to 80%) at concentrations that correspond to intracellular levels after glutamine withdrawal. Ribonucleotide reductase has been suggested as a major control point in DNA synthesis (56).…”

Section: Unclassified Structuresmentioning

confidence: 95%

The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.

Silverman¹,

Atherly²

1979

Microbiological Reviews

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“…Achyla was also hydroxyurea-sensitive [200]. Only one short communication reported evidence for a cobalamin-dependent enzyme in fungi: the RNR activity of Pithomyces chartarum extracts required BI2 [201].…”

Section: Rnr Activity In Extracts Of the Water Mouldmentioning

confidence: 99%

Ribonucleotide reductases and their occurrence in microorganisms: A link to the RNA/DNA transition

Harder

1993

FEMS Microbiology Reviews

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The evolution of a deoxyribonucleotide synthesizing ribonucleotide reductase might have initiated the transition from the ancient RNA world into the prevailing DNA world. At least five classes of ribonucleotide reductases have evolved. The ancient enzyme has not been identified. A reconstruction of the first ribonucleotide reductase requires knowledge of contemporary enzymes and of microbial evolution. Experimental work on the former focuses on few organisms, whereas the latter is now well understood on the basis of ribosomal RNA sequences. Deoxyribonucleotide formation has not been investigated in many evolutionary important microorganisms. This review covers our knowledge on deoxyribonucleotide synthesis in microorganisms and the distribution of ribonucleotide reductases in nature. Ecological constraints on enzyme evolution and knowledge deficiencies emerge from complete coverage of the phylogenetic groups.

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Regulation of fungal ribonucleotide reductase by unusual dinucleotides

Cited by 22 publications

References 15 publications

Cytidine 5′-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

Cytidine 5′-diphosphate reductase activity in phytohemagglutinin stimulated human lymphocytes

The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.

Ribonucleotide reductases and their occurrence in microorganisms: A link to the RNA/DNA transition

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