Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice

Zhou, Hui; Li, Fanglan; Wu, Meirong; Zhu, Jiangxiong; Wang, Yuanfeng; Wei, Xinlin

doi:10.1039/d3fo00355h

Cited by 8 publications

(5 citation statements)

References 44 publications

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“…On the other hand, black tea demonstrated the capacity to improve glucose uptake and metabolism, thereby reducing postprandial blood glucose levels. Furthermore, it had a positive impact on the composition of intestinal microorganisms by increasing the abundance of beneficial bacteria in the body [45]. This study revealed that two Japanese green tea varieties, Indo and Cha Chuukanbohon Nou 6, have potent DPP-4 inhibitory activity.…”

Section: Effect Of Tea Products With Different Fermentation Degrees O...mentioning

confidence: 78%

“…Simultaneously, it led to a reduction in the levels of Clostridium and Bacteroides. Importantly, deeply fermented black tea exhibited a more significant effect in this context [45]. Additionally, administering extracts of both conventional black tea and selenium-enriched black tea to hyperglycemic mice can modify the composition of intestinal microorganisms.…”

Section: Regulation Of Gut Microbiotamentioning

confidence: 95%

“…For example, Zhou conducted a 5-week intervention using tea extracts on diabetic mice induced by a high-fat diet. The results indicated a positive correlation between the water extracts of stir-fried green tea and congou black tea with GSK expression levels, and a negative correlation with the gluconeogenesis-related enzyme G6P [45]. Another study demonstrated that intervention with white tea water extract in diabetic mice induced by a high-fat diet and streptozotocin activated the AMPK pathway.…”

Section: Inhibition Of Gluconeogenesis Pathwaymentioning

confidence: 95%

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Research Progress on the Effect and Mechanism of Tea Products with Different Fermentation Degrees in Regulating Type 2 Diabetes Mellitus

Li,

Zhang,

Cui

et al. 2024

Foods

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A popular non-alcoholic beverage worldwide, tea can regulate blood glucose levels, lipid levels, and blood pressure, and may even prevent type 2 diabetes mellitus (T2DM). Different tea fermentation levels impact these effects. Tea products with different fermentation degrees containing different functional ingredients can lower post-meal blood glucose levels and may prevent T2DM. There are seven critical factors that shed light on how teas with different fermentation levels affect blood glucose regulation in humans. These factors include the inhibition of digestive enzymes, enhancement of cellular glucose uptake, suppression of gluconeogenesis-related enzymes, reduction in the formation of advanced glycation end products (AGEs), inhibition of dipeptidyl peptidase-4 (DPP-4) activity, modulation of gut flora, and the alleviation of inflammation associated with oxidative stress. Fermented teas can be used to lower post-meal blood glucose levels and can help consumers make more informed tea selections.

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Section: Effect Of Tea Products With Different Fermentation Degrees O...mentioning

confidence: 78%

Section: Regulation Of Gut Microbiotamentioning

confidence: 95%

Section: Inhibition Of Gluconeogenesis Pathwaymentioning

confidence: 95%

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Research Progress on the Effect and Mechanism of Tea Products with Different Fermentation Degrees in Regulating Type 2 Diabetes Mellitus

Li,

Zhang,

Cui

et al. 2024

Foods

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“…PI3K further activates Akt, which can further activate downstream proteins, promote intracellular energy metabolism, increase glucose consumption in the body, promote fatty acid oxidation metabolism, and inhibit liver lipid synthesis. The activation of IRS-1 protein can also promote insulin activation, regulate the body’s gluconeogenesis process, and inhibit the conversion of nonsugar substances into glucose in the body . As shown in Figure D, compound 75 significantly upregulated the expression of IRS-1, PI3K, and Akt phosphorylation in HepG2 cells after administration, suggesting that the hypoglycemic mechanism of 75 may be related to the regulation of the IRS-1/PI3K/Akt signaling pathway.…”

Section: Resultsmentioning

confidence: 94%

Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents

Yang,

Ying,

Cheng

et al. 2024

J. Med. Chem.

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PTP1B, a promising target for insulin sensitizers in type 2 diabetes treatment, can be effectively degraded using proteolysis-targeting chimera (PROTAC). This approach offers potential for long-acting antidiabetic agents. We report potent bifunctional PROTACs targeting PTP1B through the E3 ubiquitin ligase cereblon. Western blot analysis showed significant PTP1B degradation by PROTACs at concentrations from 5 nM to 5 μM after 48 h. Evaluation of five highly potent PROTACs revealed compound 75 with a longer PEG linker (23 atoms), displaying remarkable degradation activity after 48 and 72 h, with DC 50 values of 250 nM and 50 nM, respectively. Compound 75 induced selective degradation of PTP1B, requiring engagement with both the target protein and CRBN E3 ligase, in a ubiquitination and proteasome-dependent manner. It significantly reduced blood glucose AUC 0−2h to 29% in an oral glucose tolerance test and activated the IRS-1/PI3K/Akt signaling pathway in HepG2 cells, showing promise for long-term antidiabetic therapy.

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“…Enormous evidence has shown that tea and its contained bioactive compounds have positive effect on health, including inhibition of cancer cells ( 13 ), anti-inflammatory attributes ( 14 ), cardiovascular protection ( 15 ), enhancement of liver function ( 16 ), blood sugar regulation ( 17 , 18 ), neuroprotective qualities ( 19 ), promotion of skin health ( 20 , 21 ), and favorable effects on bone health ( 22 ), whereas their specific action mechanisms are still unclear. Recent research has underscored the gut microbiota may play a pivotal role in the health benefits of tea ( 23 , 24 ). For example, the application of tea polysaccharides conjugates (TPS) in Ulcerative colitis (UC) mice significantly altered the composition of the gut microbiome, contributing to the restoration of intestinal homeostasis ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice

Shi,

Guo,

Zhou

et al. 2024

Front. Nutr.

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IntroductionBlack tea, a beverage consumed worldwide, possesses favorable effects on gastrointestinal tract, including nourishing stomach and promoting digestion. Nevertheless, its specific effects on intestinal homeostasis remains inconclusive.MethodsWe applied black tea to mice prior to inducing colitis with DSS and then monitored their body weight and disease activity index (DAI) daily. When sacrificed, we measured intestinal permeability and conducted analyses of mucin and tight junction proteins. We detected inflammatory cytokines, immune cells, and related inflammatory signaling pathways. In addition, the gut microbiota was analyzed through 16S rRNA sequencing, and the concentrations of short-chain fatty acids (SCFAs) were also measured.ResultsThe results showed that black tea-treated group significantly rescued the DSS-disrupted intestinal structure. It reduced the relative abundance of the pathogenic bacterium Turicibacter, while increased the abundance of beneficial bacteria norank_f_Muribaculaceae and restored the contents of SCFAs such as acetate, propionate, and butyrate. It also protected the intestinal barrier by reducing the levels of immune response-related factors (e.g., TNF-α, IL-6, IL-1β) and increasing the expression of tight junction proteins (TJs) (e.g., ZO-1, occludin). Furthermore, black tea exhibited the capacity to suppress the expression of MMP-9 and ICAM-1, as well as to inhibit the activation of NF-κB signaling pathway.DiscussionOur findings provide a theoretical framework that elucidates the mechanisms by which black tea preserves intestinal homeostasis, highlighting its potential as a preventive strategy against intestinal disruptions. This study contributes to the understanding of the dietary effects of black tea on gastrointestinal health.

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Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice

Abstract: High-sugar and -fat diets (HSFD) have become a primary risk factor for diabetes, and diet intervention shows a substantial effect on the prevention and management of hyperglycemia. In this study,...

Cited by 8 publications

References 44 publications

Research Progress on the Effect and Mechanism of Tea Products with Different Fermentation Degrees in Regulating Type 2 Diabetes Mellitus

Research Progress on the Effect and Mechanism of Tea Products with Different Fermentation Degrees in Regulating Type 2 Diabetes Mellitus

Discovery of Selective Proteolysis-Targeting Chimera Degraders Targeting PTP1B as Long-Term Hypoglycemic Agents

Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice

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