Regulation of granulopoiesis by transcription factors and cytokine signals

Ward, Alister C.; Loeb, David M.; Soede-Bobok, Amrita A.; Touw, Ivo P.; Friedman, Alan D.

doi:10.1038/sj.leu.2401808

Cited by 112 publications

(102 citation statements)

References 311 publications

(276 reference statements)

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“…The CCAAT/enhancer binding protein a (CEBPa) is the main regulator of granulocyte differentiation. CEBPa controls the transcription of the gene coding for the granulocyte colony stimulating factor receptor (GCSF-R) (Smith et al, 1996;Ward et al, 2000). In CML-BC, Bcr-Abl expression leads to the suppression of GCSF-R mRNA transcription, possibly through inhibition of CEBPa mRNA translation.…”

Section: Control Of Cebpa Translation In Myeloid Differentiation and mentioning

confidence: 99%

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Ostareck-Lederer

Ostareck

2004

Biology of the Cell

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Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.

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Section: Control Of Cebpa Translation In Myeloid Differentiation and mentioning

confidence: 99%

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Ostareck-Lederer

Ostareck

2004

Biology of the Cell

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“…28 This difference likely reflects the ability of C/EBPa to both induce a G1/S cell cycle arrest and to induce the expression of myeloid-specific genes such as MPO and LF, 29 whereas WT1 (À/À) does not induce the expression of myeloid-specific genes. A G1/S arrest may be necessary for terminal phases of granulopoiesis, such as LF expression and nuclear maturation, but is not in and of itself sufficient for this process.…”

Section: Cell Linementioning

confidence: 99%

An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation

et al. 2003

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“…Excellent reviews on the expression and function of key myeloid transcription factors have been published elsewhere. [16][17][18][19] However, the other roles that signaling proteins play in facilitating myeloid differentiation have only recently begun to emerge. These emerging roles include the regulation of cell cycle control proteins, apoptosis regulatory proteins and intracellular kinase signaling pathways, and will be the focus of this review.…”

Section: Introductionmentioning

confidence: 99%

Signal transduction pathways that contribute to myeloid differentiation

Miranda

Johnson

2007

Leukemia

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The production of mature, differentiated myeloid cells is regulated by the action of hematopoietic cytokines on progenitor cells in the bone marrow. Cytokines drive the process of myeloid differentiation by binding to specific cell-surface receptors in a stage-and lineage-specific manner. Following the binding of a cytokine to its cognate receptor, intracellular signal-transduction pathways become activated that facilitate the myeloid differentiation process. These intracellular signaling pathways may promote myelopoiesis by stimulating expansion of a progenitor pool, supporting cellular survival during the differentiation process, or by directly driving the phenotypic changes associated with differentiation. Ultimately, pathways that drive the differentiation process converge on myeloid transcription factors, including PU.1 and the C/EBP family, that are critical for differentiation to proceed. While much is known about the cytokines, cytokine receptors and transcription factors that regulate myeloid differentiation, less is known about the precise roles that specific signaling mediators play in promoting myeloid differentiation. Recently, however, the application of novel pharmacologic inhibitors, siRNA strategies, and transgenic and knockout models has begun to shed light on the involvement and function of signaling pathways in normal myeloid differentiation. This review will discuss the roles that key signaling pathways and mediators play in myeloid differentiation.

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Regulation of granulopoiesis by transcription factors and cytokine signals

Cited by 112 publications

References 311 publications

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation

Signal transduction pathways that contribute to myeloid differentiation

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