Regulation of growth-related genes by nutrition in paralarvae of the common octopus (Octopus vulgaris)

serrana, Daniel García de la; Pérez, Montse; Nande, Manuel; Hernández‐Urcera, Jorge; Pérez, Evaristo; Coll-Lladó, Clara; Hollenbeck, Christopher M.

doi:10.1016/j.gene.2020.144670

Cited by 5 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…WMISH analysis in nonfeeding and rapamycin-treated starfish larvae suggested that the TOR-mediated feeding-nutrient sensing pathway controls adult skeletogenesis upstream of the GRN. Together with the previous studies in larvae of C. elegans 33 and octopus 34 , our data suggests that the feeding-TOR pathway is conserved in bilaterians. Of note, in nonfeeding larvae, unlike in TOR-inhibited larvae, the expression of ets1/2 in the posterior coelom was detected in approximately half of the larvae.…”

Section: Discussionsupporting

confidence: 87%

Gene regulation of adult skeletogenesis in starfish and modifications during gene network co-option

Yamazaki

Yamakawa

Morino

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The larval skeleton of the echinoderm is believed to have been acquired through co-option of a pre-existing gene regulatory network (GRN); that is, the mechanism for adult skeleton formation in the echinoderm was deployed in early embryogenesis during echinoderm diversification. To explore the evolutionary changes that occurred during co-option, we examined the mechanism for adult skeletogenesis using the starfish Patiria pectinifera. Expression patterns of skeletogenesis-related genes (vegf, vegfr, ets1/2, erg, alx1, ca1, and clect) suggest that adult skeletogenic cells develop from the posterior coelom after the start of feeding. Treatment with inhibitors and gene knockout using transcription activator-like effector nucleases (TALENs) suggest that the feeding-nutrient sensing pathway activates Vegf signaling via target of rapamycin (TOR) activity, leading to the activation of skeletogenic regulatory genes in starfish. In the larval skeletogenesis of sea urchins, the homeobox gene pmar1 activates skeletogenic regulatory genes, but in starfish, localized expression of the pmar1-related genes phbA and phbB was not detected during the adult skeleton formation stage. Based on these data, we provide a model for the adult skeletogenic GRN in the echinoderm and propose that the upstream regulatory system changed from the feeding-TOR-Vegf pathway to a homeobox gene-system during co-option of the skeletogenic GRN.

show abstract

Section: Discussionsupporting

confidence: 87%