Abstract:There is an urgent need to define mechanisms underlying pancreatic adenocarcinoma (PDA) development. Our studies of ubiquitin ligases that may underlie PDA development led us to identify and characterize RNF125. We show that RNF125 exhibits nuclear expression in acinar cells, with reduced and largely cytosolic expression in ductal cells, PanIN and PDA specimens.We find that RNF125 interacts with histone deacetylase 2 (HDAC2) and promotes its noncanonical K63-linked ubiquitination. Inhibition of HDAC2 activity … Show more
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