2020
DOI: 10.1126/sciimmunol.aau4594
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Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity

Abstract: The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this barrier remains understudied compared with other anatomical barrier sites. Here, we review basic aspects of oral mucosal histology, the oral microbiome, and common and clinically significant diseases that present at oral mucosal barriers. We particularly focus on the role of interleukin-17 (IL-17)/T helper 17 (TH17) responses in protec… Show more

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Cited by 159 publications
(152 citation statements)
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References 129 publications
(178 reference statements)
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“…Of relevance to C. albicans infections, the AMP β -defensin 3 is essential to prevent OPC in mice (61), but has no direct orthologue in humans (90, 91). Moreover, the composition of the microbiome varies among species, including in the mouth (92, 93).…”
Section: Discussionmentioning
confidence: 99%
“…Of relevance to C. albicans infections, the AMP β -defensin 3 is essential to prevent OPC in mice (61), but has no direct orthologue in humans (90, 91). Moreover, the composition of the microbiome varies among species, including in the mouth (92, 93).…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, other sets of innate immune cells have attracted the attention of several research groups due to the essential role of IL-17-mediated responses for antifungal immunity. Notably, these responses are crucial for anti-Candida immunity in oral mucosal tissues (Gaffen et al, 2011;Li et al, 2018;Gaffen and Moutsopoulos, 2020). In the oropharyngeal candidiasis (OPC) mouse model, mice deficient in IL-17RA, IL-17RC, or IL-23p19 show increased susceptibility to oral candidiasis (Conti et al, 2009;Ho et al, 2010), independently on the C. albicans strain used (Schönherr et al, 2017).…”
Section: Anti-candida Innate Immunity At the Mucosamentioning
confidence: 99%
“…In fact, recall infection experiments in mice showed a robust antigenspecific response mediated by IL-17-producing CD4 + T cells (Hernández-Santos et al, 2013), and C. albicans is the major fungal inducer of human Th17 responses (Bacher et al, 2019). Thus, since currently there are no markers to discriminate native and conventional Th17 cells, their precise role in the IL-17 release during mucosal candidiasis in humans is not completely known (Gaffen and Moutsopoulos, 2020).…”
Section: Anti-candida Innate Immunity At the Mucosamentioning
confidence: 99%
“…The most extensively studied cytokine of this family is IL-17A-a pro-inflammatory cytokine that plays a crucial role in host defense against bacterial and fungal infections. Apparently, IL-17 signaling is essential for host protection against C. albicans infection, particularly in the oral environment [30]. For instance, mice lacking the IL-17 receptor or its key downstream signaling adaptor Act1 were highly susceptible to OPC [98].…”
Section: Il-17 Orchestrates Innate and Adaptive Immunitymentioning
confidence: 99%
“…This group includes certain nTh17 cells, γδ T cells, iNKT and an innate lymphoid cell (ILC) population known as ILC3 [31]. IL-17-secreting cells represent a small cell population in healthy oral tissues in mice and humans [30]. In healthy human gingiva Th17 cells constitute most IL-17 secreting cells, while in mice, the predominant IL-17-secreting cells are γδ T cells, followed by nTh17 cells and ILC3s, though their contribution is controversial [28].…”
Section: Il-17 Orchestrates Innate and Adaptive Immunitymentioning
confidence: 99%