Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver

Zhang, Yue; Le, Yuan; Bu, Pengli; Cheng, Xinjian

doi:10.1016/j.tox.2020.152521

Toxicology

2020

DOI: 10.1016/j.tox.2020.152521

|View full text |Cite

Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver

Yue Zhang

Yuan Le

Pengli Bu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15) PFOA may activate nuclear receptors, such as peroxisome proliferator-activated receptor alpha (PPAR-α), resulting in changes in transcripts related to fatty acid metabolism, inflammation, exogenous metabolism, and cell cycle regulation. [16][17][18] As an environmental pollutant, PFOS exposure can cause many negative health effects, influencing the liver, kidney, thyroid, reproductive system, and immune systems. 19) A previous study has shown that co-exposure to PFOS and polychlorinated biphenyl (PCB) 126 can promote redox stress and induce high levels of oxidized phospholipids, which eventually lead to some cardiovascular and cerebrovascular diseases and inflammatory diseases.…”

mentioning

confidence: 99%

The Association of Hypertension with Perfluoroalkyl and Polyfluoroalkyl Substances

Yang,

Zhang,

Shen

et al. 2023

Int. Heart J.

View full text Add to dashboard Cite

Perfluoroalkyl and polyfluoroalkyl substance (PFAS) is a large group of fluorinated synthetic chemicals, e. g., perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorodecanoic acid (PFDA), and perfluorononanoic acid (PFNA). Many epidemiological studies have found that PFAS exposure is associated with hypertension risk, but others possess a different opinion. Overall, the relationship between PFASs and hypertension risk remains controversial. We sought to conduct a systematic review and meta-analysis to clarify the association between PFAS exposure and human risk of hypertension.We conducted a meta-analysis based on population-involving studies published from 1975 to 2023, which we collected from Web of Science, PubMed, and Embase databases. The odds ratio (OR) and standardized mean difference (SMD), with their 95% confidence interval (CI), were used to assess the risk of hypertension with PFAS exposure. The statistical heterogeneity among studies was assessed with the Q-test and I 2 statistics. Research publications related to our meta-analysis topic were systematically reviewed.Fourteen studies involving 71,663 participants, in which 26,281 suffered hypertension, met the inclusion criteria. Our analyses suggest that exposure to general PFAS (OR = 1.09, 95% CI = 1.04-1.14) or PFOS (OR = 1.17, 95% CI = 1.05-1.30) is associated with hypertension risk. Specifically, elevated levels of general PFAS (SMD = 0.25, 95% CI = 0.08-0.42), PFHxS (SMD = 0.17, 95% CI = 0.07-0.27), and PFDA (SMD = 0.08, 95% CI = 0.02-0.13) are associated with a high risk of hypertension.Our meta-analysis indicates that PFAS exposure is a risk factor for hypertension, and increased hypertension risk is associated with higher PFAS levels. Further study may eventually provide a better and more comprehensive elucidation of the potential mechanism of this association.

show abstract

mentioning

confidence: 99%

The Association of Hypertension with Perfluoroalkyl and Polyfluoroalkyl Substances

Yang,

Zhang,

Shen

et al. 2023

Int. Heart J.

View full text Add to dashboard Cite

show abstract

Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food

Naidenko

Andrews

Temkin

et al. 2021

IJERPH

View full text Add to dashboard Cite

The development of high-throughput screening methodologies may decrease the need for laboratory animals for toxicity testing. Here, we investigate the potential of assessing immunotoxicity with high-throughput screening data from the U.S. Environmental Protection Agency ToxCast program. As case studies, we analyzed the most common chemicals added to food as well as per- and polyfluoroalkyl substances (PFAS) shown to migrate to food from packaging materials or processing equipment. The antioxidant preservative tert-butylhydroquinone (TBHQ) showed activity both in ToxCast assays and in classical immunological assays, suggesting that it may affect the immune response in people. From the PFAS group, we identified eight substances that can migrate from food contact materials and have ToxCast data. In epidemiological and toxicological studies, PFAS suppress the immune system and decrease the response to vaccination. However, most PFAS show weak or no activity in immune-related ToxCast assays. This lack of concordance between toxicological and high-throughput data for common PFAS indicates the current limitations of in vitro screening for analyzing immunotoxicity. High-throughput in vitro assays show promise for providing mechanistic data relevant for immune risk assessment. In contrast, the lack of immune-specific activity in the existing high-throughput assays cannot validate the safety of a chemical for the immune system.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver

Cited by 2 publications

References 55 publications

The Association of Hypertension with Perfluoroalkyl and Polyfluoroalkyl Substances

The Association of Hypertension with Perfluoroalkyl and Polyfluoroalkyl Substances

Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food

Contact Info

Product

Resources

About