Regulation of human bone sialoprotein gene transcription by platelet-derived growth factor-BB

Melatonin regulates human bone sialoprotein gene transcription

“…We have reported that PKA, tyrosine kinase, ERK1/2 and PI3K regulate BSP gene transcription (31,32,36,50). Activation of PKA may induce CREB1 phosphorylation, and phospho-CREB1 can bind firmly to CRE, thereby inducing gene transcription (51).…”

“…The BSP gene promoters of rat, mouse and human have been cloned and investigated (26)(27)(28)(29). In the human BSP gene promoter, an inverted TATA box (nts -28~-23) (27) and an inverted CCAAT box (nts-54~-50) maintain basal transcription (29,30), and two cAMP response elements (CRE1; -79~-72, CRE2; -674~-667) are also present (31,32). Additionally, a fibroblast growth factor 2 (FGF2) response element (FRE; nts -96~-89) (33,34), three activating protein 1 (AP1) response elements (AP1(1); -148~-142, AP1(2); -483~-477 and AP1(3); -797~-791) (31,32), and a homeobox binding site (HOX; -200~-191) (35,36) have been characterized.…”

Fibroblast growth factor 2 regulates bone sialoprotein gene transcription in human breast cancer cells

“…Zhengyang Li 1,3) , Zhitao Wang 1,3) , Li Yang 1,3) , Xinyue Li 1,3) , Yoko Sasaki 1) , Shuang Wang 1,4) , Shouta Araki 1) , Masaru Mezawa 1) , Hideki Takai 1,2) , Youhei Nakayama 1,2) and Yorimasa Ogata Original AP1(2); -483 to -477 and AP1(3); -797 to -791) (9,10), and a homeodomain protein-binding site (HOX; -200 to -191) (7,14) have been characterized. FGF2 belongs to a large family of at least 23 related heparin-binding proteins, sharing 35-55% sequence similarity (16)(17)(18)(19)(20).…”

“…Through its binding to factor H, BSP can protect cells from complement-mediated cell lysis, which may be important for cancer cell survival (6). The human BSP gene has been cloned and partially characterized (7)(8)(9)(10). Its promoter has an inverted TATA box (nt -28 to -23) (7)(8)(9)(10), an inverted CCAAT box (nt -54 to -50) which is required for basal transcription (9)(10)(11), and two cAMP response elements (CRE1; -79 to -72 and CRE2; -674 to -667) (9,10,12).…”

“…Its promoter has an inverted TATA box (nt -28 to -23) (7)(8)(9)(10), an inverted CCAAT box (nt -54 to -50) which is required for basal transcription (9)(10)(11), and two cAMP response elements (CRE1; -79 to -72 and CRE2; -674 to -667) (9,10,12). In addition, a fibroblast growth factor 2 (FGF2) response element (FRE; -96 to -89) (9,10,(13)(14)(15), three activator protein 1 (AP1) response elements (AP1(1); -148 to -142,…”