1980
DOI: 10.1002/9780470720592.ch9
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Regulation of Human Drug Metabolism by Dietary Factors

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1980
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Cited by 16 publications
(4 citation statements)
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“…However, since both nobiletin and 8-methoxypsoralen inhibited the genotoxicity of NNK only by 50z, we suggest that other CYP enzymes may be responsible for the remaining genotoxicity of NNK in the S9 enzymes. Although nobiletin did not eŠectively aŠect the genotoxicity of BP in the present study, Conney et al (43) observed that nobiletin stimulates human liver microsomes and activates both the hydroxylation of BP and the metabolism of a‰atoxin B1 to mutagens. Nobiletin also stimulates oxidative metabolism of zoxazolamine by rat liver microsomes (44) and acetaminophen by human liver microsome (45).…”
Section: Discussioncontrasting
confidence: 77%
“…However, since both nobiletin and 8-methoxypsoralen inhibited the genotoxicity of NNK only by 50z, we suggest that other CYP enzymes may be responsible for the remaining genotoxicity of NNK in the S9 enzymes. Although nobiletin did not eŠectively aŠect the genotoxicity of BP in the present study, Conney et al (43) observed that nobiletin stimulates human liver microsomes and activates both the hydroxylation of BP and the metabolism of a‰atoxin B1 to mutagens. Nobiletin also stimulates oxidative metabolism of zoxazolamine by rat liver microsomes (44) and acetaminophen by human liver microsome (45).…”
Section: Discussioncontrasting
confidence: 77%
“…Secondly, there remain significant differences between recruitment centres in measured serum levels, even after dose adjustments are made. Given that CYP450 genotype shows no association with recruitment centre, these variations may be due to environmental differences between populations recruited to the different centres across Europe; for example, diet is known to affect drug metabolism rates (Conney et al, 1980).…”
Section: Discussionmentioning
confidence: 99%
“…Secondly, there remain significant differences between recruitment centres in measured serum levels, even after dose adjustments are made. Given that CYP450 genotype shows no association with recruitment centre, these variations may be due to environmental differences between populations recruited to the different centres across Europe; for example, diet is known to affect drug metabolism rates (Conney et al, 1980). Finally, variability in drug metabolism rates and serum concentration of antidepressant could play a role in the occurrence of drug-related side-effects, which are important predictors of study drop out (Mitchell, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Due to multiscale biological activity of PPs, scientific investigations promoted these naturally occurring metabolites in preventing AFs complications ( 324 , 408 ). Studies suggested that PPs can directly or indirectly affect the metabolism of AFs, leading to significant reduction of AFs toxicity ( 409 414 ). These interesting results purported that PPs substantially interfered with the formation of AFs-HSA complex ( 191 ), reduced the construction of AFs-DNA adducts ( 415 ), regulated AFs-induced inflammation ( 416 ), and also improved detoxification of AFs in liver ( 417 ).…”
Section: Pps Mechanism Of Actions For Improving Afs Complicationsmentioning
confidence: 99%