Regulation of human endothelial progenitor cell maturation by polyurethane nanocomposites

Hung, Hsin-Chia; Yang, Yi‐Chin; Lin, Yu; Lin, Shinn Zong; Kao, Wei Chien; Hsieh, Hsien-Hsu; Chu, Mei; Fu, Ru Huei; Hsu, Shan‐hui

doi:10.1016/j.biomaterials.2014.04.076

Cited by 20 publications

(18 citation statements)

References 39 publications

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“…One study showed that ePTFE seeded with EPCs significantly increased the patency, and inhibited the intimal hyperplasia in comparison to those without seeding of EPCs . Moreover, Hung et al demonstrated that EPCs seeded on polyurethane (PU) nanocomposites promoted endothelium and reduced the thrombosis effectively in vivo .…”

Section: Unipotent Stem Cellsmentioning

confidence: 99%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

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Vascular regeneration is known to play an essential role in the repair of injured tissues mainly through accelerating the repair of vascular injury caused by vascular diseases, as well as the recovery of ischemic tissues. However, the clinical vascular regeneration is still challenging. Cell-based therapy is thought to be a promising strategy for vascular regeneration, since various cells have been identified to exert important influences on the process of vascular regeneration such as the enhanced endothelium formation on the surface of vascular grafts, and the induction of vessel-like network formation in the ischemic tissues. Here are a vast number of diverse cell-based strategies that have been extensively studied in vascular regeneration. These strategies can be further classified into three main categories, including cell transplantation, construction of tissue-engineered grafts, and surface modification of scaffolds. Cells used in these strategies mainly refer to terminally differentiated vascular cells, pluripotent stem cells, multipotent stem cells, and unipotent stem cells. The aim of this review is to summarize the reported research advances on the application of various cells for vascular regeneration, yielding insights into future clinical treatment for injured tissue/organ.

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Section: Unipotent Stem Cellsmentioning

confidence: 99%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

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“…As discussed in our previously published papers, when there is incorporation of an appropriate concentration of AuNPs into different types of polymers, leading to the formation of nanocomposites, it can cause superior biocompatibility and biological performance by nanotopography cues, as well as producing a biomimic interface, subsequently changing the cell behavior. The impressive capacity of nanocomposites may be attributed to their superior biocompatibility, which is not only due to their lower monocyte counts and platelet activation but also their higher cell growth, migration, and differentiation capabilities [ 59 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Physical Gold Nanoparticle-Decorated Polyethylene Glycol-Hydroxyapatite Composites Guide Osteogenesis and Angiogenesis of Mesenchymal Stem Cells

et al. 2021

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In this study, polyethylene glycol (PEG) with hydroxyapatite (HA), with the incorporation of physical gold nanoparticles (AuNPs), was created and equipped through a surface coating technique in order to form PEG-HA-AuNP nanocomposites. The surface morphology and chemical composition were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), UV–Vis spectroscopy (UV–Vis), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and contact angle assessment. The effects of PEG-HA-AuNP nanocomposites on the biocompatibility and biological activity of MC3T3-E1 osteoblast cells, endothelial cells (EC), macrophages (RAW 264.7), and human mesenchymal stem cells (MSCs), as well as the guiding of osteogenic differentiation, were estimated through the use of an in vitro assay. Moreover, the anti-inflammatory, biocompatibility, and endothelialization capacities were further assessed through in vivo evaluation. The PEG-HA-AuNP nanocomposites showed superior biological properties and biocompatibility capacity for cell behavior in both MC3T3-E1 cells and MSCs. These biological events surrounding the cells could be associated with the activation of adhesion, proliferation, migration, and differentiation processes on the PEG-HA-AuNP nanocomposites. Indeed, the induction of the osteogenic differentiation of MSCs by PEG-HA-AuNP nanocomposites and enhanced mineralization activity were also evidenced in this study. Moreover, from the in vivo assay, we further found that PEG-HA-AuNP nanocomposites not only facilitate the anti-immune response, as well as reducing CD86 expression, but also facilitate the endothelialization ability, as well as promoting CD31 expression, when implanted into rats subcutaneously for a period of 1 month. The current research illustrates the potential of PEG-HA-AuNP nanocomposites when used in combination with MSCs for the regeneration of bone tissue, with their nanotopography being employed as an applicable surface modification approach for the fabrication of biomaterials.

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“…Another study showed that EPC-seeded mixtures of polyurethane (PU, which might be produced to individual match the microenvironment of vascular tissue precisely) and Au-NPs differentiate into endothelial cells in vitro, and the enhanced maturation of the EPCs with the nanocomposites of PU-Au-NPs was more remarkable, probably because of the SDF-1α/CXCR4 signaling pathway in vitro. Furthermore, other experiments showed that EPCs seeded on PU-Au-coated catheters effectively reduced thrombosis by differentiating into endothelial cells in vivo (Hung et al, 2014b). However, no clinical trials have explored whether this kind of therapy would have a favorable effect on PVD patients.…”

Section: Nps Mimic the Ecm Environmentmentioning

confidence: 99%

The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease

Sun

et al. 2020

Front. Bioeng. Biotechnol.

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Cardiovascular disease (CVD) is currently one of the primary causes of mortality and morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in regulating stem cell behavior because of their special features, including shape, size, aspect ratio, surface charge, and surface area. In terms of cardiac disease, NPs can facilitate gene delivery in stem cells, track the stem cells in vivo for long-term monitoring, and enhance retention after their transplantation. The advantages of applying NPs in peripheral vascular disease treatments include facilitating stem cell therapy, mimicking the extracellular matrix environment, and utilizing a safe non-viral gene delivery tool. However, the main limitation of NPs is toxicity, which is related to their size, shape, aspect ratio, and surface charge. Currently, there have been many animal models proving NPs' potential in treating CVD, but no extensive applications of stem-cell therapy using NPs are available in clinical practice. In conclusion, NPs might have significant potential uses in clinical trials of CVD in the future, thereby meeting the changing needs of individual patients worldwide.

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Regulation of human endothelial progenitor cell maturation by polyurethane nanocomposites

Cited by 20 publications

References 39 publications

Cell‐based strategies for vascular regeneration

Cell‐based strategies for vascular regeneration

Physical Gold Nanoparticle-Decorated Polyethylene Glycol-Hydroxyapatite Composites Guide Osteogenesis and Angiogenesis of Mesenchymal Stem Cells

The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease

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