Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1β-mediated induction

Ducale, Ashley E.; Ward, Susan I.; Dechert, Tracey; Yager, Dorne R.

doi:10.1152/ajpgi.00494.2004

Cited by 18 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This would be similar to the p38-dependent up-regulation of Has1 and Has2 noted in synovial fibroblasts and intestinal mesenchymal cells, respectively, when subjected to mediators of inflammation (86,87). Similarly, Has3 can be induced by proinflammatory cytokines in synovial membrane cells (88).…”

Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-supporting

confidence: 53%

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Rauhala

Hämäläinen

Salonen

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Accumulation of epidermal hyaluronan is an early event in UVB-induced squamous cell carcinomas. Results: UVB increases keratinocyte hyaluronan synthesis by up-regulating hyaluronan synthases Has1 and -2 via p38 and Has3 via Ca 2ϩ /calmodulin-dependent protein kinase II (CaMKII) signaling. Conclusion: UVB triggers deposition of epidermal hyaluronan through at least two signaling pathways. Significance: Increased hyaluronan synthesis is an inherent feature of keratinocyte adaptation to radiation injury.

show abstract

Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-supporting

confidence: 53%

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Rauhala

Hämäläinen

Salonen

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…29 However, in human intestinal mesenchymal cells, HAS2 expression by IL-1b is mediated by ERK and p38, but not by JNK. 30 These discrepancies may be due to the different characteristics of the particular stimulants and cell types used.…”

Section: Discussionmentioning

confidence: 99%

Pirfenidone Attenuates the IL-1β–Induced Hyaluronic Acid Increase in Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy

Chung

Jeon

Choi

et al. 2014

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…However, the effectiveness of the cytokines may differ in various cell types (Kennedy et al, 2000;Ducale et al, 2005;Meran et al, 2007). Additionally, HAS activity may also be regulated by posttranslational modifications such as phosphorylation (Vigetti et al, 2009) and ubiquitination (Karousou et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Melanoma Cells Control HA Synthesis in Peritumoral Fibroblasts via PDGF-AA and PDGF-CC: Impact on Melanoma Cell Proliferation

Willenberg

Saalbach

Simon

et al. 2012

Journal of Investigative Dermatology

View full text Add to dashboard Cite

The microenvironment surrounding tumors has an important role in tumor progression. Fibroblasts (Fbs) of the tumor stroma receive signals from tumors and transform the extracellular matrix, thus supporting tumor growth, motility, and metastasis. The matrix component hyaluronan (HA) has a pivotal role in tumor progression. Here we analyzed the cell populations that synthesize HA in human malignant melanoma (MM) cells and studied the regulatory network between MM cells and stromal Fbs controlling HA synthesis. Tissue analysis indicated that Fbs are the main source of HA in the stroma of melanoma, whereas MM themselves synthesize only minute amounts of HA. In vitro, Fb-derived HA is mainly produced by hyaluronan synthase 2 (HAS2) and enhances proliferation of MM. Proteins secreted by MM can further increase HA synthesis in Fbs in a phosphatidylinositol 3/mitogen-activated protein-kinase-dependent manner. Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-α and thus induce HAS2-mediated HA synthesis in Fbs. In conclusion, we have identified a complex interaction of MM with its surrounding microenvironment by demonstrating that MM by the release of PDGF-AA and PDGF-CC upregulate HA synthesis in Fbs, which in turn stimulates MM proliferation in a paracrine manner.

show abstract

Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1β-mediated induction

Abstract: Ducale, Ashley E., Susan I. Ward, Tracey Dechert, and Dorne R. Yager. Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1␤-mediated induction.

Cited by 18 publications

References 63 publications

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Pirfenidone Attenuates the IL-1β–Induced Hyaluronic Acid Increase in Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy

Melanoma Cells Control HA Synthesis in Peritumoral Fibroblasts via PDGF-AA and PDGF-CC: Impact on Melanoma Cell Proliferation

Contact Info

Product

Resources

About