Regulation of Hypertrophic and Apoptotic Signaling Pathways by Reactive Oxygen Species in Cardiac Myocytes

Sabri, Abdelkarim; Hughie, Hoyt H.; Lucchesi, Pamela A.

doi:10.1089/152308603770380034

Cited by 219 publications

(164 citation statements)

References 84 publications

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“…Obesity-related oxidative stress, inflammation, and activation of the renin-angiotensin system can induce cardiac remodeling with increased cardiac myocyte and connective tissue matrix accumulation. [33][34][35] The causality of the observed association between childhood adiposity and adulthood LVM cannot be established by this observational study. Persistence of adiposity over time plays a role in this regard.…”

Section: Discussionmentioning

confidence: 77%

Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood

et al. 2004

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Background-The association between left ventricular hypertrophy, an independent predictor of cardiovascular (CV) morbidity and mortality, and CV risk factors has been well documented in childhood and in adulthood. However, information on the relationship between left ventricular mass (LVM) in adults and longitudinal measurements of CV risk factors from childhood to adulthood is limited. Methods and Results-LVM was obtained with 2D M-mode echocardiography in a community-based sample of 467 young adults (71% white and 29% black) aged 20 to 38 years who were examined an average of 6 times for CV risk factors from childhood to adulthood. The average follow-up period was 21.5 years. The cumulative burden of each risk factor was calculated as the area under the curve for each individual. Compared with whites, blacks had greater LVM (indexed to height 2.7 ; PϽ0.05). In multiple regression analyses, adiposity (measured as body mass index) in childhood, adiposity and systolic blood pressure in adulthood, and the cumulative burden of adiposity and systolic blood pressure from childhood to adulthood were significant predictors of LVM index in young adults. Conclusions-These observations, by showing that adiposity beginning in childhood is a consistent predictor of LVM in young adults, underscore the importance of obesity in the development of left ventricular hypertrophy and the need for early prevention.

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Section: Discussionmentioning

confidence: 77%

Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood

et al. 2004

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“…It has been suggested that increased ROS concentrations may lead to apoptosis during embryo culturing [9]. Among different ROS, H 2 O 2 at high concentrations induces apoptosis [26]. Therefore, this study was conducted to monitor the levels of H 2 O 2 within oocytes to indirectly assess ROS toxicity.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Improves In Vitro Development of Porcine Oocytes by Decreasing Reactive Oxygen Species Levels.

Kang

Kwon

Park

et al. 2011

Biology of Reproduction

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Quercetin is a plant-derived flavonoid found in fruits or vegetables that has antioxidant properties and acts as a free radical scavenger. We investigated the effects of quercetin on porcine oocyte nuclear maturation and embryonic development after parthenogenetic activation. We then evaluated the antioxidant activities of quercetin by measuring reactive oxygen species (ROS) levels in matured oocytes. Immature oocytes were untreated or treated with 1, 10, and 50 μg/mL quercetin during in vitro maturation (IVM). Quercetin treatment did not improve oocyte nuclear maturation, but significantly higher blastocyst rates (p ＜ 0.05) of parthenogenetically activated oocytes were achieved when the IVM medium was supplemented with an adequate concentration of quercetin (1 μg/mL). However, cleavage rates and blastocyst cell numbers were not affected. Oocytes treated with 1 or 10 μg/mL quercetin had significantly lower (p ＜ 0.05) levels of ROS than the control and group treated with the highest concentration of quercetin (50 μg/mL). Moreover, this highest concentration was detrimental to oocyte nuclear maturation and blastocyst formation. Based on our findings, we concluded that exogenous quercetin reduces ROS levels during oocyte maturation and is beneficial for subsequent embryo development.

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“…Nitrosylation is a physiologically important post-translational modification that affects a wide variety of proteins involved in a number of cellular processes. The term of nitrosative stress implied the hazardous levels of nitrosylation, a situation analogous to and taking place in the presence of oxidative stress which have been implicated in cardiac apoptosis, muscle dysfunction and cell injury [18][19][20]. NO also acts through soluble guanylyl cyclase and activates this enzyme to raise cyclic GMP levels.…”

Section: Discussionmentioning

confidence: 99%

Chronic nitrates blunt the effects of not only nitric oxide but also natriuretic peptides in cardiac myocytes

Tan¹,

Zhang²,

Anyadike³

et al. 2007

Pharmacological Research

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Abstractexposure to nitrates causes tachyphylaxis to nitric oxide (NO), which reduces the effects of the second messenger cyclic GMP. We tested the hypothesis that prolonged exposure to NO would also blunt the effects of natriuretic peptides. Cardiac myocytes were isolated from control (N=7) and chronic nitroglycerin (patched, N=7) rabbits. Patched animals received a transdermal nitroglycerin patch (0.3 mg/hr for 5 days). Myocyte function was determined at baseline, after CNP (C-type natriuretic peptide, 10 −8 and 10 −7 M) or BNP (Brain natriuretic peptide, 10 −8 and 10 −7 M) or SNAP (S-nitroso-N-acetyl-penicilliamine, a NO donor, 10 −6 and 10 −5 M) followed by KT5823 (a cyclic GMP protein kinase inhibitor, 10 −6 M). Soluble and particulate guanylyl cyclase activities were measured in vitro and phosphoprotein analysis was performed. In control animals, CNP 10 −8 M (5.14±0.5%) and 10 −7 M (4.4±0.7%) significantly reduced percentage shortening from baseline (6.1±1.6%). KT5823 restored percentage shortening to 4.9±0.8%. Similar data were obtained with BNP and SNAP. In patched animals, CNP, BNP, SNAP had no significant effects on percentage shortening. The data on maximal rate of shortening and relaxation were consistent with these results. Guanylyl cyclase activities were not different in the control and patched animals. The myocytes from control and patched animals had similar protein phosphorylation patterns. Our data suggested that in addition to NO, the responses to both natriuretic peptides were downregulated after chronic exposure to nitroglycerin, but these effects were not due to changes in either guanylyl cyclase or cyclic GMP protein kinase, suggesting an altered downstream pathway.

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Regulation of Hypertrophic and Apoptotic Signaling Pathways by Reactive Oxygen Species in Cardiac Myocytes

Cited by 219 publications

References 84 publications

Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood

Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood

Quercetin Improves In Vitro Development of Porcine Oocytes by Decreasing Reactive Oxygen Species Levels.

Chronic nitrates blunt the effects of not only nitric oxide but also natriuretic peptides in cardiac myocytes

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