Regulation of hypopharyngeal gland activity and oogenesis in honey bee (Apis mellifera) workers

Wegener, Jakob; Zhi, Huang; Lorenz, Matthias; Bienefeld, Kaspar

doi:10.1016/j.jinsphys.2009.05.003

Cited by 36 publications

(22 citation statements)

References 70 publications

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“…HPG development was thus rated using an established scale (Hess 1942), which uses the shape and density of the acini as the main criterion for classification and ranks them from by stage of development: (1) atrophied; (2) slightly swollen with noticeable spacing between acini; (3) swollen with small spacing between acini, capable of producing brood food; and (4) fully developed and tightly clustered, channel obscured by acini. Glands were additionally assigned to one of three classes according to lobe morphology (Wegener et al 2009) as models predict that eβ can accelerate behavioral maturation (Maisonnasse et al 2010) and we wanted to determine if forager HPG morphology was present in our nurse-aged bees. Class 1, typical of young broodless workers, consists of glands with small acini showing an uneven surface.…”

Section: Methodsmentioning

confidence: 99%

Queen and young larval pheromones impact nursing and reproductive physiology of honey bee (Apis mellifera) workers

Traynor

Conte

Page

2014

Behav Ecol Sociobiol

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Several insect pheromones are multifunctional and have both releaser and primer effects. In honey bees (Apis mellifera), the queen mandibular pheromone (QMP) and e-beta-ocimene (eβ), emitted by young worker larvae, have such dual effects. There is increasing evidence that these multifunctional pheromones profoundly shape honey bee colony dynamics by influencing cooperative brood care, a fundamental aspect of eusocial insect behavior. Both QMP and eβ have been shown to affect worker physiology and behavior, but it has not yet been determined if these two key pheromones have interactive effects on hypopharyngeal gland (HPG) development, actively used in caring of larvae, and ovary activation, a component of worker reproductive physiology. Experimental results demonstrate that both QMP and eβ significantly suppress ovary activation compared to controls but that the larval pheromone is more effective than QMP. The underlying reproductive anatomy (total ovarioles) of workers influenced HPG development and ovary activation, so that worker bees with more ovarioles were less responsive to suppression of ovary activation by QMP. These bees were more likely to develop their HPG and have activated ovaries in the presence of eβ, providing additional links between nursing and reproductive physiology in support of the reproductive ground plan hypothesis.Electronic supplementary materialThe online version of this article (doi:10.1007/s00265-014-1811-y) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Queen and young larval pheromones impact nursing and reproductive physiology of honey bee (Apis mellifera) workers

Traynor

Conte

Page

2014

Behav Ecol Sociobiol

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“…We found the gene cluster to be upregulated in Low strain ovaries. Ecdysteroid signaling, which presumably is also upregulated in Low strain ovaries, enhances the royal-jelly-producing (and strongly MRJP-expressing) hypopharyngeal glands of workers in addition to influencing ovarian physiology (Wegener et al, 2009). Cross-fostering studies indicate that low strain nurse workers provide different nutritional environments to developing larvae than high strain nurse workers (Linksvayer et al 2009b, perhaps as a result of differential MRJP1 expression.…”

Section: Genomic Gene Clustersmentioning

confidence: 99%

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Wang

Kocher

Linksvayer

et al. 2012

Journal of Experimental Biology

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Fat body expression of hormone receptor-like in 46 (HR46) and phosphoinositide-dependent kinase-1 (PDK1) correlates with ovary size as well as worker division of labor (Wang et al., 2009). HR46 is a possible nuclear hormone receptor for ecdysteroid hormones Accepted 28 September 2011 SUMMARY Several lines of evidence support genetic links between ovary size and division of labor in worker honey bees. However, it is largely unknown how ovaries influence behavior. To address this question, we first performed transcriptional profiling on worker ovaries from two genotypes that differ in social behavior and ovary size. Then, we contrasted the differentially expressed ovarian genes with six sets of available brain transcriptomes. Finally, we probed behavior-related candidate gene networks in wild-type ovaries of different sizes. We found differential expression in 2151 ovarian transcripts in these artificially selected honey bee strains, corresponding to approximately 20.3% of the predicted gene set of honey bees. Differences in gene expression overlapped significantly with changes in the brain transcriptomes. Differentially expressed genes were associated with neural signal transmission (tyramine receptor, TYR) and ecdysteroid signaling; two independently tested nuclear hormone receptors (HR46 and ftz-f1) were also significantly correlated with ovary size in wild-type bees. We suggest that the correspondence between ovary and brain transcriptomes identified here indicates systemic regulatory networks among hormones (juvenile hormone and ecdysteroids), pheromones (queen mandibular pheromone), reproductive organs and nervous tissues in worker honey bees. Furthermore, robust correlations between ovary size and neural-and endocrine response genes are consistent with the hypothesized roles of the ovaries in honey bee behavioral regulation. Supplementary material available online at

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“…It is known to be synthesized mainly in the female fat body in sex and stage-specific manners, is secreted into the hemolymph, and then is sequestered by developing ovaries and oocytes (Raikhel and Dhadialla, 1992;Hagedorn et al, 1998;Giorgi et al, 1999). Unfortunately, with the exception of Athalia rosae (Hatakeyama et al, 1990), Nasonia vitripennis (Dong et al, 2008), and Apis mellifera (Wegener et al, 2009), information regarding the correlation between the secretion patterns of vitellogenin and ovarian development in hymenopteran insects is limited. Ovarian development during diapause in Osmia spp.…”

Section: Introductionmentioning

confidence: 99%

Ovarian development and secretion of vitellogenin protein during the wintering period and after emergence in the hornfaced bee, Osmia cornifrons

Lee

Yoon

et al. 2015

Journal of Asia-Pacific Entomology

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Regulation of hypopharyngeal gland activity and oogenesis in honey bee (Apis mellifera) workers

Cited by 36 publications

References 70 publications

Queen and young larval pheromones impact nursing and reproductive physiology of honey bee (Apis mellifera) workers

Queen and young larval pheromones impact nursing and reproductive physiology of honey bee (Apis mellifera) workers

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Ovarian development and secretion of vitellogenin protein during the wintering period and after emergence in the hornfaced bee, Osmia cornifrons

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