Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

Abstract

Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

“…The study also reported that along with the elevation of IFN- In specific cellular immunity, IL-12 is notably associated with the stimulation of IFN-γ production by NK and T cells as well as the augmentation of NK cell cytotoxicity [77].…”

Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L.

“…+ T cells to become interferon--producing T helper 1 (Th1) effectors in cell-mediated immune responses [28]. IL-12 could also synergize with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells [29].…”

Melanoma Treatment with Intratumoral Electroporation of Tavokinogene Telseplasmid (pIL-12, Tavokinogene Telseplasmid)

“…IL-12 is a pleiotropic pro-inflammatory cytokine that activates the immune system via multiple mechanisms and is expressed by several immune cells including dendritic cells, macrophages and neutrophils [19]. IL-12 is a key Th1-polarizing cytokine along with IFN-γ [20].…”