Regulation of immune cell homeostasis and function by coronin 1

Jayachandran, Rajesh; Pieters, Jean

doi:10.1016/j.intimp.2015.03.045

Cited by 11 publications

(10 citation statements)

References 49 publications

(95 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coronin 1A is a member of the coronin family of actin-associated proteins and is highly expressed in hematopoietic cells222324. This protein contains 461 amino acids and is comprised of the following three functional domains: an amino-terminal tryptophan-aspartic acid (WD) repeat-containing region followed by a unique region and a carboxy-terminal coiled-coil domain2223.…”

mentioning

confidence: 99%

“…This protein contains 461 amino acids and is comprised of the following three functional domains: an amino-terminal tryptophan-aspartic acid (WD) repeat-containing region followed by a unique region and a carboxy-terminal coiled-coil domain2223. Because coronin 1A interacts with actin, it has been assumed to be involved in cytoskeletal regulation, however, coronin 1A-deficient macrophages exhibit intact cell motility and phagocytosis2223. On the other hand, coronin 1A has been identified as an inhibitor of the lysosomal degradation pathway by preventing the fusion of endosomes/phagosomes with lysosomes25262728.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

Ohmae

Noma

Toyomoto

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Osteoclasts degrade bone matrix proteins via the secretion of lysosomal enzymes. However, the precise mechanisms by which lysosomal components are transported and fused to the bone-apposed plasma membrane, termed ruffled border membrane, remain elusive. Here, we identified coronin 1A as a negative regulator of exocytotic release of cathepsin K, one of the most important bone-degrading enzymes in osteoclasts. The modulation of coronin 1A expression did not alter osteoclast differentiation and extracellular acidification, but strongly affected the secretion of cathepsin K and osteoclast bone-resorption activity, suggesting the coronin 1A-mediated regulation of lysosomal trafficking and protease exocytosis. Further analyses suggested that coronin 1A prevented the lipidation-mediated sorting of the autophagy-related protein LC3 to the ruffled border and attenuated lysosome–plasma membrane fusion. In this process, the interactions between coronin 1A and actin were crucial. Collectively, our findings indicate that coronin 1A is a pivotal component that regulates lysosomal fusion and the secretion pathway in osteoclast-lineage cells and may provide a novel therapeutic target for bone diseases.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

Ohmae

Noma

Toyomoto

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Whereas coronin 1 does not appear to be required for the functionality of resting macrophages, during an inflammatory stimulus coronin 1 is responsible for reprogramming the uptake pathway from phagocytosis to macropinocytosis in order to rapidly eliminate pathogens, a function that is dependent on activation of phosphoinositol (PI)-3-kinase (Bosedasgupta and Pieters, 2014 ). Furthermore, coronin 1 is largely dispensable for the functioning of B cells, mast cells, dendritic cells and natural killer cells, although the latter have been described to be affected by coronin 1 mutation in human (Moshous et al, 2013 ; Mace and Orange, 2014 ; Jayachandran and Pieters, 2015 ; Tchang et al, 2017 ). Also, coronin 1 was found to be dispensable for neutrophil function and recruitment in an in vivo model of liver injury and concanavanin A-induced hepatitis (Combaluzier and Pieters, 2009 ; Siegmund et al, 2013 ); in humans, coronin 1 has been associated with neutrophil survival and recent work has implicated coronin 1 in integrin-mediated functioning (Moriceau et al, 2009 ; Pick et al, 2017 ).…”

Section: Coronin 1 Function In Mammalian Leukocytesmentioning

confidence: 99%

From Phagocytes to Immune Defense: Roles for Coronin Proteins in Dictyostelium and Mammalian Immunity

Mori

Mode

Pieters

2018

Front. Cell. Infect. Microbiol.

Self Cite

View full text Add to dashboard Cite

Microbes have interacted with eukaryotic cells for as long as they have been co-existing. While many of these interactions are beneficial for both the microbe as well as the eukaryotic cell, several microbes have evolved into pathogenic species. For some of these pathogens, host cell invasion results in irreparable damage and thus host cell destruction, whereas others use the host to avoid immune detection and elimination. One of the latter pathogens is Mycobacterium tuberculosis, arguably one of the most notorious pathogens on earth. In mammalian macrophages, M. tuberculosis manages to survive within infected macrophages by avoiding intracellular degradation in lysosomes using a number of different strategies. One of these is based on the recruitment and phagosomal retention of the host protein coronin 1, that is a member of the coronin protein family and a mammalian homolog of coronin A, a protein identified in Dictyostelium. Besides mediating mycobacterial survival in macrophages, coronin 1 is also an important regulator of naïve T cell homeostasis. How, exactly, coronin 1 mediates its activity in immune cells remains unclear. While in lower eukaryotes coronins are involved in cytoskeletal regulation, the functions of the seven coronin members in mammals are less clear. Dictyostelium coronins may have maintained multiple functions, whereas the mammalian coronins may have evolved from regulators of the cytoskeleton to modulators of signal transduction. In this minireview, we will discuss the different studies that have contributed to understand the molecular and cellular functions of coronin proteins in mammals and Dictyostelium.

show abstract

“…While Coronin-1b and -1c are ubiquitously expressed, Coronin-1a seems to have a more restricted expression profile. Of particular note is the expression of Coronin-1a in T cells, thymocytes, macrophages, neutrophils, neurons, and endothelial cells (Jayachandran & Pieters, 2015; Moshous & de Villartay, 2014; Suo et al, 2014). Interestingly, many of the cells expressing Coronin-1a are polarized and require active cytoskeleton rearrangement and protein transport.…”

Section: The Coronin Family Of Proteinsmentioning

confidence: 99%

“…Coronin-1a then mediates calcium release and calcineurin activation, and this pathway is required for protection from the lysosome. Loss of Coronin-1a, calcium, or calcineurin activity is sufficient to drive pathogenic phagosomes toward lysosomal fusion (Jayachandran & Pieters, 2015; Jayachandran et al, 2007). Interestingly, Coronin-1a must be oligomerized into a trimer for this protection to occur.…”

Section: Coronin-1a As a Signaling Effector Proteinmentioning

confidence: 99%

Emergent Role of Coronin-1a in Neuronal Signaling

Martorella

Barford

Winkler

et al. 2017

Vitamins and Hormones

View full text Add to dashboard Cite

The Coronin family of proteins were first noted for their role in pathogen–host interactions and for modulating actin dynamics. Recently, however, Coronins have been found in a greater variety of cell types, and novel roles for the Coronins within the nervous system have been discovered. In the immune system, Coronin-1a enables Mycobacterium tuberculosis to evade lysosomal destruction. This activity appears to be analogous to protection of the NGF–TrkA signaling endosome during sympathetic nervous system development that is required for survival signaling. Similarly, others have implicated Coronin-1a in GPCR signaling during the formation of excitatory connections in the central nervous system. Its role in multiple signaling pathways suggests that it may influence cross talk between key pathways (TrkA, GPCRs) during neurodevelopment. Here, we review the role of Coronin-1a in neural development and function.

show abstract

Regulation of immune cell homeostasis and function by coronin 1

Cited by 11 publications

References 49 publications

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

From Phagocytes to Immune Defense: Roles for Coronin Proteins in Dictyostelium and Mammalian Immunity

Emergent Role of Coronin-1a in Neuronal Signaling

Contact Info

Product

Resources

About