1986
DOI: 10.1128/mcb.6.4.1015
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Regulation of immunoglobulin D synthesis in murine neonatal B lymphocytes.

Abstract: We analyzed the regulatory basis for the lower expression of immunoglobulin D (IgD) in lymphocytes from neonatal mice of various ages. The results indicate that the relative transcriptional rate of RNA for 8 chains is similar to adult levels even in cells which have not started to express IgD. These results suggest that very early after the initiation of > gene transcription, a defined fraction of polymerases is programmed to progress through the termination site to the 8 exons regardless of the developmental … Show more

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Cited by 11 publications
(6 citation statements)
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“…Thus transcription termination in these IgM-secreting M2 myeloma cells was completed within 1 kb following the fim polyadenylylation site. These results extend earlier studies, which did not directly measure transcription in these segments immediately following the gm polyadenylylation site (10)(11)(12)(13)(14). In contrast, transcription over this 1-kb To further define the protein-binding site located near the Am poly(A) site, a 141-bp HincII fragment (designated ,um141, see Fig.…”
supporting
confidence: 88%
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“…Thus transcription termination in these IgM-secreting M2 myeloma cells was completed within 1 kb following the fim polyadenylylation site. These results extend earlier studies, which did not directly measure transcription in these segments immediately following the gm polyadenylylation site (10)(11)(12)(13)(14). In contrast, transcription over this 1-kb To further define the protein-binding site located near the Am poly(A) site, a 141-bp HincII fragment (designated ,um141, see Fig.…”
supporting
confidence: 88%
“…Developmentally regulated transcription termination plays an important role in controlling gene expression from the complex /L+8 transcription unit encoding the heavy chains of IgM (,t) and IgD (8) (10)(11)(12)(13)(14). Although the features of transcription termination in the A+ 8 1 and 2).…”
mentioning
confidence: 99%
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“…For example, in mature resting follicular mantle B cells, more μ mRNA than δ mRNA is transcribed, but IgD is expressed at higher densities on the surface than IgM. This has been attributed to the higher stability and better translation efficiency of δ mRNA than μ mRNA and the higher turnover rate of transmembrane IgM protein (98, 99). When activated by antigen, μ exon transcription is preferentially induced and the half‐life of μ mRNA is significantly increased.…”
Section: Expression Of Igdmentioning
confidence: 99%
“…Peripheral B cells of non-transgenic mice however co-express with IgM a second type of antigen receptor (sIgD) which gradually appears during the first 1-3 weeks of age [43]. sIgM+, sIgD-B cells are only found early in ontogeny and later in organs of hematopoiesis [44,451. Mature B cells co-express IgM with up to 10-fold excess of IgD [46].…”
Section: Sigd Protects the B Cell From Eliminationmentioning
confidence: 99%