Regulation of inflammation in cancer by dietary eicosanoids

Yang, Haixia; Rothenberger, Eva; Zhao, Tong; Fan, Wendong; Kelly, Abigail; Attaya, Ahmed; Fan, Daidi; Panigrahy, Dipak; Deng, Jianjun

doi:10.1016/j.pharmthera.2023.108455

Cited by 16 publications

(7 citation statements)

References 197 publications

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“…Previous studies have shown an increase in arachidonic acid metabolites in mastitis cow feces and plasma 21 . We detected changes in 28 eicosanoids in mammary tissue, including prostaglandin F2a and prostaglandin D1, the most important active metabolites of the biologically active lipid arachidonic acid, which play a key role in the inflammatory process 40 . The upregulation of inflammatory mediators, such as IL‐1β, IL‐6, and MPO, in the mammary tissue of mastitis‐induced rats may be attributed to it.…”

Section: Discussionmentioning

confidence: 64%

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Chen,

Hu,

Ren

et al. 2024

The FASEB Journal

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Mastitis is a disease characterized by congestion, swelling, and inflammation of the mammary gland and usually caused by infection with pathogenic microorganisms. Furthermore, the development of mastitis is closely linked to the exogenous pathway of the gastrointestinal tract. However, the regulatory mechanisms governing the gut‐metabolism‐mammary axis remain incompletely understood. The present study revealed alterations in the gut microbiota of mastitis rats characterized by an increased abundance of the Proteobacteria phylum. Plasma analysis revealed significantly higher levels of L‐isoleucine and cholic acid along with 7‐ketodeoxycholic acid. Mammary tissue showed elevated levels of arachidonic acid metabolites and norlithocholic acid. Proteomic analysis showed increased levels of IFIH1, Tnfaip8l2, IRGM, and IRF5 in mastitis rats, which suggests that mastitis triggers an inflammatory response and immune stress. Follistatin (Fst) and progesterone receptor (Pgr) were significantly downregulated, raising the risk of breast cancer. Extracellular matrix (ECM) receptors and focal adhesion signaling pathways were downregulated, while blood–milk barrier integrity was disrupted. Analysis of protein‐metabolic network regulation revealed that necroptosis, protein digestion and absorption, and arachidonic acid metabolism were the principal regulatory pathways involved in the development of mastitis. In short, the onset of mastitis leads to changes in the microbiota and alterations in the metabolic profiles of various biological samples, including colonic contents, plasma, and mammary tissue. Key manifestations include disturbances in bile acid metabolism, amino acid metabolism, and arachidonic acid metabolism. At the same time, the integrity of the blood–milk barrier is compromised while inflammation is promoted, thereby reducing cell adhesion in the mammary glands. These findings contribute to a more comprehensive understanding of the metabolic status of mastitis and provide new insights into its impact on the immune system.

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Section: Discussionmentioning

confidence: 64%

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Chen,

Hu,

Ren

et al. 2024

The FASEB Journal

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“…The COX catalyzes the oxidation of arachidonic acid to the cyclic peroxide prostaglandin G 2 . Unstable endoperoxide intermediate is then converted to prostaglandin H 2 and is further metabolized to PGE 2 (Yang et al., 2023). Among prostaglandins, PGE 2 is most closely related to immunomodulatory responses.…”

Section: Resultsmentioning

confidence: 99%

Identification of lymph node adulteration in minced pork by comprehensive metabolomics and lipidomics approach based on UPLC/LTQ‐Orbitrap MS

Wang,

Jiang,

et al. 2024

Journal of Food Science

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The deliberate pork adulteration with lymph nodes is a common adulteration phenomenon, and it poses a serious threat to public health and food safety. An untargeted metabolomics and lipidomics approach based on ultrahigh performance liquid chromatography coupled with linear ion trap quadrupole‐Orbitrap high resolution mass spectrometry (MS) was used to distinguish lymph nodes from minced pork. The principal component analysis and orthogonal projection to latent structures discriminant analysis models were established with the good of fitness and predictivity. The results showed that there were significant differences in metabolites and lipids between lymph nodes and pork. A total of 16 significantly differentiated metabolites were identified, of which 1‐palmitoylglycerophosphocholine, 12,13‐dihydroxy‐9‐octadecenoic acid, and prostaglandin E2 (PGE2) were positively correlated with lymph node content and were identified as potential markers of lymph nodes. These three markers were combined to create a binary logistic regression model, and a combined‐factor exceeding 0.75 was ultimately identified as a marker for pork adulteration with lymph nodes. The desorption electrospray ionization‐MS images showed that PGE2 had a higher relative abundance in the lymph node region than in adjacent non‐lymph node regions, indicating that PGE2 was a marker that contributed significantly for identifying lymph nodes adulteration into pork. Our results provide a theoretical basis for identifying lymph node adulteration, which will contribute to combating fraud in the meat industry.

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“…Enzymes like cPLA2 catalytically release arachidonic acid bound to membrane phospholipids, which, in turn, undergo metabolism through COX, LOX, and CYP pathways, resulting in the production of prostaglandins (PGs) and thromboxanes (Txs) via the COX pathway, or leukotrienes (LTs) and hydroxyl arachidonic acid analogues (HETEs) (LOX pathway), as well as epoxy-eicosatetraenoic acid analogues (EETs) (CYP pathway). − Linoleic acid can be metabolized to produce various pro-inflammatory or anti-inflammatory factors, and it is also a precursor of arachidonic acid …”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Modulating Lipid Metabolism in C57BL/6 Mice

Wang,

Chen,

Zhang

et al. 2024

J. Agric. Food Chem.

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Lipid metabolism is closely related to obesity and its complications. Our previous study found that ginsenoside Rk3 (Rk3), a natural bioactive substance derived from ginseng, can effectively alleviate obesity-induced colitis, while its impact on the improvement of the lipid metabolism disorder remains unclear. Here, we demonstrated that Rk3 significantly alleviated inflammation, oxidative stress, and lipid dysregulation in high-fat diet-induced colitis C57BL/6 mice. The potential mechanism by which Rk3 mitigated colon inflammation in the context of obesity may involve the modulation of polyunsaturated fatty acid metabolism with specific attention to n-6 fatty acids, linoleic acid, and arachidonic acid. Rk3 intervention markedly reduced the production of pro-inflammatory factors (PGE2, PGD2, TXB2, HETE, and HODE) by inhibiting cyclooxygenase and lipoxygenase pathways, while enhancing the production of anti-inflammatory factors (EET and diHOME) via cytochrome P450 pathways. Our findings suggest that Rk3 is a potential anti-inflammatory natural drug that can improve obesity-induced intestinal inflammation by regulating lipid metabolism.

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Regulation of inflammation in cancer by dietary eicosanoids

Cited by 16 publications

References 197 publications

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Enhanced protein‐metabolite correlation analysis: To investigate the association between Staphylococcus aureus mastitis and metabolic immune pathways

Identification of lymph node adulteration in minced pork by comprehensive metabolomics and lipidomics approach based on UPLC/LTQ‐Orbitrap MS

Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Modulating Lipid Metabolism in C57BL/6 Mice

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