Regulation of innate receptor pathways by microRNAs

Preparation and properties of CF–Fe3O4–BN composite electromagnetic wave-absorbing materials

“…This result shows that the material had no obvious relaxation and resonance behavior in the entire dielectric spectrum, and the dipole orientation polarization may be the main polarization mechanism in this frequency range. 42 However, sharp peaks appeared in the range of 14-18 GHz, but the peaks were narrower, indicating that relaxation and resonance behavior may exist in this frequency range, but this phenomenon was not obvious. From the curve of 3 00 , two broad dielectric resonance peaks around CF/Fe 3 O 4 (3)/BN were found near 14 and 17 GHz, and dielectric relaxation was evident.…”

microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines

“…Viral genetic material triggers activation of the host innate immune responses, and this material is recognized by several pattern-recognition receptors (PRRs), such as Nod-like receptors (NLRs), RIG-like receptors (RLRs), and, most importantly, Toll-like receptors (TLRs, Fig. 1) [14,15]. The interaction of genetic material with each of these receptors depends on whether the material is DNA or RNA and whether the RNA is single stranded or double stranded [16].…”

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response

“…They sense double-stranded RNA, a replication intermediate for RNA viruses, leading to the production of type I IFNs in infected cells. Many miRNAs can be induced by RIG-1 signaling, and can control viral replication through regulation of the RIG-I pathway and the expression of type I interferon (50). In 2009, Hou et al first showed that in addition to two known miR-146a targets IRAK1 and TRAF6, that IRAK2, a kinase that compensates for IRAK1 to activate NF-κB, was a novel target of miR-146a (27, 39).…”