2021
DOI: 10.1101/2021.04.07.438854
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Regulation of Interorganellar Ca2+Transfer and NFAT Activation by the Mitochondrial Ca2+Uniporter

Abstract: Mitochondrial Ca2+ uptake is crucial for coupling receptor stimulation to cellular bioenergetics. Further, Ca2+ uptake by respiring mitochondria prevents Ca2+-dependent inactivation (CDI) of store-operated Ca2+ release-activated Ca2+ (CRAC) channels and inhibits Ca2+ extrusion to sustain cytosolic Ca2+ signaling. However, how Ca2+ uptake by the mitochondrial Ca2+ uniporter (MCU) shapes receptor-evoked interorganellar Ca2+ signaling is unknown. Here, we generated several cell lines with MCU-knockout (MCU-KO) as… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
4
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(6 citation statements)
references
References 73 publications
(104 reference statements)
2
4
0
Order By: Relevance
“…Growth was diminished in MCU KO MEFs ( 47 ) but unaltered in siRNA-treated MD-MB-231 breast carcinoma cells ( 42 ). In agreement with our findings, knockdown of MCU in primary B lymphocytes enhanced proliferation in response to anti-immunoglobulin M ( 69 ).
Figure 9 Schematic summarizing some of the pathways altered by the chronic loss of IP 3 Rs and MCU.
…”
Section: Discussionsupporting
confidence: 93%
See 3 more Smart Citations
“…Growth was diminished in MCU KO MEFs ( 47 ) but unaltered in siRNA-treated MD-MB-231 breast carcinoma cells ( 42 ). In agreement with our findings, knockdown of MCU in primary B lymphocytes enhanced proliferation in response to anti-immunoglobulin M ( 69 ).
Figure 9 Schematic summarizing some of the pathways altered by the chronic loss of IP 3 Rs and MCU.
…”
Section: Discussionsupporting
confidence: 93%
“…Growth was diminished in MCU KO MEFs (47) but unaltered in siRNA-treated MD-MB-231 breast carcinoma cells (42). In agreement with our findings, knockdown of MCU in primary B lymphocytes enhanced proliferation in response to anti-IgM (70).…”
Section: J O U R N a L P R E -P R O O Fsupporting
confidence: 90%
See 2 more Smart Citations
“…CRAC channels subserve slow inactivation processes as well, but SCDI, which is modulated by the uptake of Ca 2+ into mitochondria, seems to be primarily orchestrated in a STIM1-dependent manner and thus is not discussed herein [160][161][162][163].…”
Section: Ca 2+ Dependent Crac Channel Inactivationmentioning
confidence: 99%