Regulation of Intestinal Blood Flow

Matheson, Paul J.; Wilson, Mark A.; Garrison, R. Neal

doi:10.1006/jsre.2000.5862

Cited by 264 publications

(213 citation statements)

References 126 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…However, this may be a paradoxical effect whereby meal-induced elevations in insulin are acutely beneficial, but sustained hyperinsulinemia (resulting in insulin resistance and related conditions) is associated with arterial stiffness (41)(42)(43)(44)(45). Given that these postprandial reductions can be maintained hours after a meal, they also may be due in part to increased blood flow to digestive organs, with compensatory reductions in flow to other organs (46). Measurement of vascular function beyond the 4-h time point in future studies would help to clarify how long these reductions are maintained.…”

Section: Discussionmentioning

confidence: 99%

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Richter

Skulas‐Ray

Gaugler

et al. 2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Background: Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects. Objective: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (w1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin responses. Design: Healthy, overweight or obese [mean 6 SEM body mass index (in kg/m 2 ): 31 6 0.5] adults (mean 6 SEM age: 28 6 2 y; 17 men and 13 women) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by $1 wk for men and w1 mo for women to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. Results: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P , 0.002) and significantly increased triglycerides, insulin, and glucose at all time points (P , 0.001) relative to baseline. Conclusions: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other polyphenol-rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.Am J Clin Nutr 2017;105:313-22.

show abstract

Section: Discussionmentioning

confidence: 99%

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Richter

Skulas‐Ray

Gaugler

et al. 2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…The response of vessels to food stimulus (gastric emptying and chyme progression) is of key importance in the control of gut blood flow following feeding. [24][25][26] Gounaris et al 27 reported that gastric emptying time was significantly shorter in preterm neonates Table 1 Demographic characteristics and clinical variables of 18 infants enrolled in the SMA BFV study…”

Section: Discussionmentioning

confidence: 99%

Nasal continuous positive airway pressure affects pre- and postprandial intestinal blood flow velocity in preterm infants

2007

View full text Add to dashboard Cite

Objective: To measure the effect of nasal continuous positive airway pressure (CPAP) on intestinal blood flow velocity responses to enteral feedings and left ventricular output (LVO).Study Design: Eighteen infants completed the study (birth weight 1793±350 g, gestational age 32.1±1.1 weeks). On the day infants were weaned from CPAP to room air, pre-and postprandial (0, 30, 60 and 90 min after feeding) mean velocity (MV), peak systolic velocity (PSV) and end diastolic velocity (EDV) were measured for one feeding given when receiving CPAP ('on CPAP'), and for one feeding given after CPAP had been discontinued ('off CPAP'). Preprandial LVO was measured before and after CPAP discontinuation.Result: MV and PSV were significantly lower when infants were on CPAP (P<0.05). Maximum postprandial MV, PSV and EDV occurred at 30 min when on CPAP and at 60 min when off CPAP. Preprandial LVO was similar when infants were on and off CPAP. Keywords: nutrition; neonate; Doppler ultrasound; CPAP belly syndrome; respiratory distress syndrome; cardiac output Introduction Nasal continuous positive airway pressure (CPAP) is used increasingly for the treatment of respiratory distress in premature neonates. Compared with intubation or mechanical ventilation, CPAP is associated with decreased incidence of bronchopulmonary dysplasia and sepsis, and with a trend toward decreased incidence of retinopathy of prematurity and intraventricular hemorrhage.

show abstract

“…3,4 Intestinal blood flow is regulated by numerous factors including cardiovascular status, neural control, humoral substances and local control. 5,6 Extrinsic factors that can affect splanchnic blood flow in preterm infants include the type and volume of enteral nutrition given, 3,[7][8][9][10] and various pharmacologic agents, including indomethacin 11,12 and caffeine. 13,14 Although factors that can affect intestinal blood flow have been identified, little is known about factors that may affect the rate at which SMA BFV increases in newborn preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Factors that influence mesenteric artery blood flow velocity in newborn preterm infants

2006

View full text Add to dashboard Cite

Objectives: To identify demographic and clinical variables that relate to the postnatal increase in intestinal blood flow velocity in preterm infants.Study design: Fasting or preprandial peak systolic velocity (PSV) and time-averaged mean velocity (TAMV) in the superior mesenteric artery were measured once each day for the first 5 days of life. We investigated the relationship between blood flow velocity and the following variables: birth weight, gestational age, feeding volumes, number of days to reach full feeding volumes, type of feeding given, continuous positive airway pressure (CPAP) administration and hyperalimentation (HAL) administration.Results: Twenty-five infants with a mean birth weight of 1740 g and mean gestational age of 31.8 weeks were studied. There were significant increases in PSV (P<0.001) and TAMV (P ¼ 0.005) from postnatal day 1 to 5. The postnatal increase in TAMV and PSV was attenuated in infants administered CPAP or HAL for X3 days; the results remained significant after controlling for birth weight and gestational age. There was a significant correlation (P<0.02) between volume of enteral feedings given on 2 of 5 days for TAMV, and on 1 of 5 days for PSV.Conclusions: These data support previous findings of significant increases in intestinal blood flow in preterm infants during the first week of life, and of inconsistent effects of enteral feeding volumes on fasting or preprandial intestinal blood flow. The reasons for, and the clinical implications of, attenuated increases in postnatal intestinal blood flow in infants on CPAP or HAL require further investigation.

show abstract

Regulation of Intestinal Blood Flow

Cited by 264 publications

References 126 publications

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Nasal continuous positive airway pressure affects pre- and postprandial intestinal blood flow velocity in preterm infants

Factors that influence mesenteric artery blood flow velocity in newborn preterm infants

Contact Info

Product

Resources

About