Regulation of intracellular free magnesium in central nervous system injury

Vink, Robert

doi:10.2741/vink

Cited by 60 publications

(27 citation statements)

References 77 publications

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“…Mechanically gated ion channels were activated in response to the negative pressure application (suction). Pressure range was 1.333-2.666 kPa (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Electrophysiologymentioning

confidence: 99%

“…Moreover, evidence has accumulated to suggest that extracellular Mg 2+ concentration can rapidly regulate intracellular Mg 2+ and has functional effects in a variety of tissues under physiological conditions and in pathophysiology. Specifically, dynamic changes in free Mg 2+ have been shown to play a pivotal role in endothelial cell functions [8,9] and in the brain following neurotrauma [10]. Now Mg 2+ is considered a promising neuroprotective agent in the therapy of acute ischaemic stroke and vascular damages.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium permeation through mechanosensitive channels: single-current measurements

et al. 2006

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, mean conductance values for inward currents carried by Mg 2+ were rather similar, being equal to 6.8 ± 0.5 and 6.4 ± 0.5 pS, respectively. The estimation of the channel-selective permeability according to constant field equation is obviously limited due to saturation effects. We conclude that the detection of single currents is the main evidence for Mg 2+ permeation through membrane channels activated by stretch. Our single-current measurements document Mg 2+ influx through MS channels in the plasma membrane of leukaemia cells.

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“…Mechanically gated ion channels were activated in response to the negative pressure application (suction). Pressure range was 1.333-2.666 kPa (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Electrophysiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnesium permeation through mechanosensitive channels: single-current measurements

et al. 2006

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“…This effect of magnesium valproate could be abolished by bicuculine.These findings suggest that the action on the postsynaptic GABA effect may be involved also in magnesium-valproate antimaniacal action (Cao & Peng , 1993). The neuroprotective magnesium effect in CNS is important not only for the recovery process after various injury ( Vink & Cernak 2000 ) but also to reduce the maniacal agitation. Machado-Viera R. et al 2009 showed that the neurotrophic effect of lithium is very important for neuro protection (Rowe & Chuang 2004 ) and for prophylaxis of acute mood effects and one of the main targets of lithium intracellular action is GSK-3 .…”

Section: Intractions Between Mood Modulator and Bivalent Cations 41 mentioning

confidence: 86%

Bivalent Cations in Bipolar Disorders

Nechifor¹,

Văideanu²,

Crivoi³

2012

Bipolar Disorder - A Portrait of a Complex Mood Disorder

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“…As a result, its use for the treatment of SCI is no longer explored. In contrast, the potential neuroprotective mechanisms of magnesium include the blockade of voltage-gated calcium channels and of NMDA receptors (Vink and Cernak, 2000). Multiple independent laboratories have reported the neuroprotective benefits of magnesium in animal models of SCI, such as improved biochemical, physiological, histological, and locomotor recovery outcomes.…”

Section: Ligand-gated Ion Channels Ionotropic Glutamate Channelsmentioning

confidence: 99%

Ion channel blockers and spinal cord injury

Liu

et al. 2011

J. Neurosci. Res.

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The activation of a delayed secondary cascade of unsatisfactory cellular and molecular responses after a primary mechanical insult to the spinal cord causes the progressive degeneration of this structure. Disturbance of ionic homeostasis is part of the secondary injury process and plays an integral role in the early stage of spinal cord injury (SCI). The secondary pathology of SCI is complex and involves disturbance of the homeostasis of K(+) , Na(+) , and Ca(2+) . The effect of ion channel blockers on chronic SCI has also been proved. In this Mini-Review, we provide a comprehensive summary of the effects of ion channel blockers on the natural responses after SCI. Combination therapy is based on the roles of ions and disturbance of their homeostasis in SCI. The effects of ion channel blockers suggest that they have potential in the treatment of SCI, although the complexity of their effects shows that further knowledge is needed before they can be applied clinically.

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Regulation of intracellular free magnesium in central nervous system injury

Cited by 60 publications

References 77 publications

Magnesium permeation through mechanosensitive channels: single-current measurements

Magnesium permeation through mechanosensitive channels: single-current measurements

Bivalent Cations in Bipolar Disorders

Ion channel blockers and spinal cord injury

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