Regulation of ion transport by histamine in human colon

Effect of histamine on the electrophysiology of the human parietal pleura

“…Other hormones, such as insulin, have also been shown previously to obstruct this process by blocking such ion transporters (Kouritas et al 2010). In a study by Traynor et al histamine decreased the net Na + absorption in porcine distal colon (Traynor et al 1993), but amiloride did not inhibit its effect in rat caecum (Homaidan et al 1997) or in human colon (Keely et al 1995). Combining the aforementioned with the results from the present study, one can speculate that histamine-induced electrochemical changes in pleura are mediated by ion transporters,…”

“…H 1 receptors seem to play the most important role; in airway epithelia (Flynn et al 2009, Chan et al 1987, in vascular epithelia (Flynn et al 2009), in nostrils (Yang et al 2003), in Fallopian tubes and ovaries (Downing et al 1999(Downing et al , 2002 and in human colon (Keely et al 1995).…”

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

“…[21][22][23] H 1 Rs are involved in mediating sensorineural signaling and vascular dilatation. 24 Activation of H 1 R is known to regulate food and water intake and diurnal feeding rhythm.…”

Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 release

“…TTX pretreatment inhibits CCh-stimulated Cl¦ secretion in the rat (Diener et al 1988) and mouse (this study) but not in human (Keely et al 1995). The combined pretreatment of TTX and indomethacin abolishes Cl¦ secretion in the rat (Strabel & Diener, 1995) but does not reveal K¤ secretion, as it does in the mouse (this study).…”