2014
DOI: 10.1016/j.bbrc.2013.12.128
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Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin

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Cited by 18 publications
(19 citation statements)
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“…In primary human keratinocyte culture, cyanidin (Cya) upregulated the expressions of LCE3A, LCE3B and LCE3E under conditions both at 60 mmol/L calcium (low calcium) and 1.2 mmol/L calcium (high calcium) (Austin et al, 2014). Tape stripping to induce superficial skin injury also upregulated LCE3A/3C/3D/3E expressions, and however, other LCE genes were expressed at moderate levels in normal skin, but were downregulated in psoriatic skin or superficial injury after tape stripping (Bergboer et al, 2011).…”
Section: Lce3bmentioning
confidence: 99%
“…In primary human keratinocyte culture, cyanidin (Cya) upregulated the expressions of LCE3A, LCE3B and LCE3E under conditions both at 60 mmol/L calcium (low calcium) and 1.2 mmol/L calcium (high calcium) (Austin et al, 2014). Tape stripping to induce superficial skin injury also upregulated LCE3A/3C/3D/3E expressions, and however, other LCE genes were expressed at moderate levels in normal skin, but were downregulated in psoriatic skin or superficial injury after tape stripping (Bergboer et al, 2011).…”
Section: Lce3bmentioning
confidence: 99%
“…We have shown here that the presence of risk alleles caused overexpression of specific LCE3 genes. However, this is in sharp contrast to the fact that analogs of Vitamin D3 used to treat psoriasis (1,25-dihydroxyvitamin D3) functions by increasing LCE3 expression, which subsequently heals the disease 35 . Higher LCE3 expression thus appears as protective.…”
Section: Discussionmentioning
confidence: 89%
“…LCE3 gene cluster spans ~60 kb and comprises five genes (LCE3A, 3B, 3C, 3D and 3E) within the EDC (PSORS4) at chromosome 1q21. Because of the strategic role of these genes in epidermal barrier repair and their reported upregulation in psoriatic skin 34 , many later studies focused on the LCE3 genes 35 36 37 38 39 . It has previously been demonstrated that the expression of LCE3 genes were markedly induced after superficial injury of the normal skin 34 40 .…”
mentioning
confidence: 99%
“…The endocrine VDR ligand (1,25D), as well as novel VDR ligands delphinidin and cyanidin, have previously been shown to upregulate LCE3 gene expression to some extent [ 11 , 12 ]. Further, a VDRE has been identified adjacent to the LCE3A gene [ 11 ] and is not affected by the LCE3C_LCE3B deletion ( Figure 1 ).…”
Section: Introductionmentioning
confidence: 99%