2004
DOI: 10.1080/10739680490266199
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Regulation of Leukocyte Recruitment by Local Wall Shear Rate and Leukocyte Delivery

Abstract: Leukocytes are delivered to venules in excess of the capacity of the local endothelium to support interactions. Elevated shear forces increase leukocyte recruitment to the vessel wall, which correlates to elevated rolling flux. In contrast, leukocyte firm adhesion is primarily affected by the activation state of the tissue and not by hemodynamic factors. Overall, the capacity of endothelial cells to support leukocyte interactions primarily regulates leukocyte recruitment and is not limited by leukocyte supply.

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Cited by 23 publications
(27 citation statements)
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References 38 publications
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“…Furthermore, leukocytosis, which occurs in inflammation, could contribute to an elevated rate of cell arrest. However, it has been shown that firm adhesion of leukocytes is primarily determined by the activation state of the inflamed tissue and not by hemodynamic factors, and that the size of the circulating leukocyte pool (peripheral blood leukocyte counts) has an influence on the number of rolling, but not adherent, cells (17). Our IVM results in PGIA seem to be consistent with these notions.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…Furthermore, leukocytosis, which occurs in inflammation, could contribute to an elevated rate of cell arrest. However, it has been shown that firm adhesion of leukocytes is primarily determined by the activation state of the inflamed tissue and not by hemodynamic factors, and that the size of the circulating leukocyte pool (peripheral blood leukocyte counts) has an influence on the number of rolling, but not adherent, cells (17). Our IVM results in PGIA seem to be consistent with these notions.…”
Section: Discussionsupporting
confidence: 87%
“…The number of circulating leukocytes (i.e., leukocyte supply) might influence the frequency of leukocyteendothelium interactions (17), and peripheral blood leukocyte counts usually increase during inflammation. As expected, a moderate degree of leukocytosis (mainly due to increased granulocyte counts) occurred in the mice between the prearthritic time point and day 10 of PGIA ( Figure 3D).…”
Section: Resultsmentioning
confidence: 99%
“…Microcirculatory analysis also included the determination of vessel diameter and RBC velocity before thrombus induction with calculation of vascular wall shear rates, based on the Newtonian definition γ ¼ 8 Â V =D , where V represents the RBC-velocity divided by 1.6 according to the Baker-Wayland factor [21] and D represents the individual inner vessel diameter. The wall shear rate calculated might differ from values given in studies using different methods, such as the dual-slit photodiode technique and Doppler flowmetry [22,23]; however, it will fit well with values found in studies using the line-shift method or comparable systems [20,24,25].…”
Section: In Vivo Thrombosis Modelsupporting
confidence: 46%
“…Acute inflammation results in upregulation of selectin molecules expressed by the ECs (10) and increased leukocyte-EC interactions (12,14,16,29). The overall expression of other adhesion molecules such as ICAM-1 also increases after proinflammatory stimuli (19); however, the expression patterns and location of that increase are not known and are addressed in these experiments.…”
Section: Icam-1 Expression After Activation With Tnf-␣mentioning
confidence: 98%
“…In selected animals, activated conditions were established in the tissue by intrascrotal injection of mouse recombinant TNF-␣ (SigmaAldrich): 0.5 g of TNF-␣ in 0.25 ml of saline was injected 4 h before the start of the surgical preparation (12).…”
Section: Animal Preparationmentioning
confidence: 99%