Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABA<sub>A</sub> receptor

Ehlen, J. Christopher; Paul, Ketema N.

doi:10.1152/ajpregu.90878.2008

Cited by 32 publications

(33 citation statements)

References 55 publications

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“…Perhaps light is communicated to the pacemaker during the day via NMDA receptors located on interneurons or presynaptic terminals. Interestingly, injection of [4,5,6,7-tetrahy dro-isoxazolo[5,4- c ]pyridine-3-ol] (THIP), a drug thought to be a GABA A -TONIC receptor agonist, into the SCN in vivo does not induce phase advances during the subjective day (Ehlen and Paul, 2009). In contrast, diazepam, which enhances GABA A -PHASIC receptor conductance, induces phase advances when given during the subjective day in vitro (McElroy et al, 2009).…”

Section: Role Of Gaba In Entrainment Of the Circadian Pacemakermentioning

confidence: 99%

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Albers

Walton

Gamble

et al. 2017

Frontiers in Neuroendocrinology

133

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Virtually every neuron within the suprachiasmatic nucleus (SCN) communicates via GABAergic signaling. The extracellular levels of GABA within the SCN are determined by a complex interaction of synthesis and transport, as well as synaptic and non-synaptic release. The response to GABA is mediated by GABAA receptors that respond to both phasic and tonic GABA release and that can produce excitatory as well as inhibitory cellular responses. GABA also influences circadian control through the exclusively inhibitory effects of GABAB receptors. Both GABA and neuropeptide signaling occur within the SCN, although the functional consequences of the interactions of these signals are not well understood. This review considers the role of GABA in the circadian pacemaker, in the mechanisms responsible for the generation of circadian rhythms, in the ability of non-photic stimuli to reset the phase of the pacemaker, and in the ability of the day-night cycle to entrain the pacemaker.

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Section: Role Of Gaba In Entrainment Of the Circadian Pacemakermentioning

confidence: 99%

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Albers

Walton

Gamble

et al. 2017

Frontiers in Neuroendocrinology

133

View full text Add to dashboard Cite

show abstract

“…Collectively, these studies indicate that GABA regulates SCN neuronal activity, modulates photic signaling, and serves as an output signal to downstream tissues (Wang, et al 2003). For modulation of photic signaling, an important role has been demonstrated for both GABA A and GABA B receptors (Belenky et al 2003; Biggs and Prosser 1998; Ehlen and Paul 2009; Gillespie et al 1997; Novak, et al 2004). In contrast, GABA A receptor signaling is thought to be the strongest local regulator of SCN network activity (Albus et al 2005; Fan, et al 2015; Kim and Dudek 1992; Shimura, et al 1996; Strecker et al 1997).…”

Section: Scn Coupling Mechanismsmentioning

confidence: 99%

Collective timekeeping among cells of the master circadian clock

Evans

2016

Journal of Endocrinology

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The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the master circadian clock that coordinates daily rhythms in behavior and physiology in mammals. Like other hypothalamic nuclei, the SCN displays an impressive array of distinct cell types characterized by differences in neurotransmitter and neuropeptide expression. Individual SCN neurons and glia are able to display self-sustained circadian rhythms in cellular function that are regulated at the molecular level by a 24 h transcriptional-translational feedback loop. Remarkably, SCN cells are able to harmonize with one another to sustain coherent rhythms at the tissue level. Mechanisms of cellular communication in the SCN network are not completely understood, but recent progress has provided insight into the functional roles of several SCN signaling factors. This review discusses SCN organization, how intercellular communication is critical for maintaining network function, and the signaling mechanisms that play a role in this process. Despite recent progress, our understanding of SCN circuitry and coupling is far from complete. Further work is needed to map the circuitry of the SCN fully and define the signaling mechanisms that allow for collective timekeeping in the SCN network.

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“…До последнего времени о рецепторах GABA было из-вестно, что в основном они экспрессируются в нейронах оптических долей мозга насекомых [14] аналогично их роли в ЦНС позвоночных [21], принимая участие в цир-кадианной регуляции нейронной активности. Экспрессия гена rdl в репродуктивных органах имаго колорадского жука, выявленная нами как повышенное содержание мРНК rdl в гонадах активных особей, еще не вступивших в фазу формирования диапаузы (рис.…”

Section: результаты и обсуждениеunclassified

Transcription activity of genes taking part in Colorado potato beetle diapause regulation and its changes under the fipronil impact

Nikonorov

Syrtlanova

Kitaev

et al. 2016

Ecological genetics

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Background. The peculiarities of transcription activity of genes taking part in Colorado potato beetle diapause regulation have been investigated under the laboratory conditions in winter diapause initiation phase and in the middle of winter. Materials and Methods. Excerpt of summer generation (2015 year.) adults divided in active and inactive individuals in groups treated or untreated by fipronil in sublethal concentration (0.0001% a.i.) in the diapause initiation and maintenance phases. Quantitative real-time PCR used for comparing evaluation of transcription activity in muscles and gonads tissues for genes DP1, fer, DAT1, DAT2, EcR, Ldace-1 and rdl. Results. In gonads of active adults unlike the quiescent ones detected presence of rdl subunit of GABA-А receptor mRNA. In the middle of diapause maintenance phase in fipronil-treated adults revealed the increasing of mRNA content in muscles and gonads for genes of reserve proteins DP1, defensive proteins DAT1, DAT2, ferritin fer, gene of ecdysone receptor EcR and gene coding the acetylcholinesterase Ldace-1. Conclusion. The assumption advanced about the fipronil blocking the GABA-receptor binding thereby has significant impact to regulation processes accompanying the development of diapause states.

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Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABA_A receptor

Abstract: Ehlen JC, Paul KN. Regulation of light's action in the mammalian circadian clock: role of the extrasynaptic GABAA receptor.

Cited by 32 publications

References 55 publications

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus

Collective timekeeping among cells of the master circadian clock

Transcription activity of genes taking part in Colorado potato beetle diapause regulation and its changes under the fipronil impact

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