2010
DOI: 10.1016/j.pneurobio.2010.08.004
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Regulation of local translation at the synapse by BDNF

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Cited by 118 publications
(96 citation statements)
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References 147 publications
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“…The initiation and elongation steps of translation are considered rate-limiting, being subjected to regulation at multiple sites (Herbert and Proud, 2007;Santos et al, 2010). BDNF is thought to act at different levels to increase translation activity, by altering the phosphorylation of proteins involved in the initiation and elongation steps of protein synthesis.…”
Section: Bdnf and Regulation Of Translation Machinerymentioning
confidence: 99%
See 1 more Smart Citation
“…The initiation and elongation steps of translation are considered rate-limiting, being subjected to regulation at multiple sites (Herbert and Proud, 2007;Santos et al, 2010). BDNF is thought to act at different levels to increase translation activity, by altering the phosphorylation of proteins involved in the initiation and elongation steps of protein synthesis.…”
Section: Bdnf and Regulation Of Translation Machinerymentioning
confidence: 99%
“…The neurotrophin brain-derived neurotrophic factor (BDNF) has been shown to play a key role as mediator of activity-induced LTP in the hippocampus as well as in other brain regions (Bramham and Messaoudi, 2005;Cowansage et al, 2010;Lu et al, 2008;Minichiello, 2009;Park and Poo, 2013;Santos et al, 2010). The early effects of BDNF result from the modification of components already available at the synapse (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…These findings also suggest that FMRP might control shared signaling molecules that are key players to regulate neurotransmitter-mediated signaling and protein synthesis. The two major pathways regulating neurotransmitter-induced protein synthesis in neurons are the ERK1/2 and the PI3K/mTOR (mammalian target of rapamycin) pathways (Banko et al, 2006;Nagai et al, 2007;Schicknick et al, 2008;Santos et al, 2010;Zhou et al, 2010). Both pathways also play crucial roles for intracellular signaling, and many of the above discussed dysregulated neurotransmitter-dependent signaling mechanisms in FXS are regulated or mediated via ERK1/2 and/or PI3K signaling (Figure 1).…”
Section: Targeting Downstream Signaling Molecules In Fxsmentioning
confidence: 99%
“…Specifically, mTOR influences protein translation at spines via two downstream pathways which are responsible for promoting translation of different pools of mRNAs [97]. One pathway involves S6 kinase and the eukaryotic initiation factor 4B (eIF4B), while the other comprises the eukaryotic initiation factor 4E (eIF4E) and its binding protein 1 (4E-BP1) [97][98][99].…”
Section: Trkb Signalingmentioning
confidence: 99%