2021
DOI: 10.1016/j.plipres.2021.101095
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Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

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Cited by 100 publications
(53 citation statements)
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“…Other molecules, with p values ranging between 10E−12 and 0.02, comprise upregulated lipids. The annotated lipid with lower p value was potentially a PE 42:10, that is, a long chain PE with a very high unsaturation, which might be derived from the elongation steps of docosahexaenoic‐containing lipids (Xie et al., 2021). Similarly, we found a dimethyl‐PE (PE‐NMe2(32:1) which is formed by sequential methylation of phosphatidylethanolamine as part of a mechanism for biosynthesis of phosphatidylcholine (Blusztajn et al., 1979).…”
Section: Resultsmentioning
confidence: 99%
“…Other molecules, with p values ranging between 10E−12 and 0.02, comprise upregulated lipids. The annotated lipid with lower p value was potentially a PE 42:10, that is, a long chain PE with a very high unsaturation, which might be derived from the elongation steps of docosahexaenoic‐containing lipids (Xie et al., 2021). Similarly, we found a dimethyl‐PE (PE‐NMe2(32:1) which is formed by sequential methylation of phosphatidylethanolamine as part of a mechanism for biosynthesis of phosphatidylcholine (Blusztajn et al., 1979).…”
Section: Resultsmentioning
confidence: 99%
“…Within this context, S. senegalensis has been shown to have a higher LC-PUFA biosynthesising capacity compared to most of its marine counterparts [ 21 , 30 ]. In the present study, we investigated the combined effect of diet and salinity, the latter being regarded as an environmental factor through which LC-PUFA biosynthesis can be modulated in telosts [ 18 , 39 ].…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, Elovl are enzymes that catalyse the first and rate-limiting condensation reaction in the fatty acid (FA) elongation pathway [ 16 ]. There exist eight different Elovl present in vertebrates (Elovl1-8) [ 18 ], among which Elovl5 and Elovl2 have well-established roles in LC-PUFA biosynthesis since they are highly efficient in the elongation of PUFA substrates with chain lengths varying from 18 to 22 carbons [ 16 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Almost 60% of the glucose taken up by HCC cells is used for the synthesis of fatty acids (17)(18)(19). Sterol regulatory element binding protein (SREBP)-1 is the most important transcription factor in lipid metabolism (20)(21)(22). In HCC cells, SREBP-1 mediates the transcription of genes related to the syntheses of fatty acids and triglycerides (17)(18)(19).…”
Section: Introductionmentioning
confidence: 99%