Regulation of Macrophage Polarization and Wound Healing

Ferrante, Christopher; Leibovich, Samuel

doi:10.1089/wound.2011.0307

Cited by 480 publications

(413 citation statements)

References 19 publications

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“…While macrophages are the predominant cell type found at the ulcer margins in diabetic and venous ulcers, they are unable to steer the repair process towards the proliferative phase. Under normal wound healing conditions, macrophages have the ability to switch between different phenotypes, to wit, the classically activated M1 macrophages observed in the early phase of infl ammation, and the M2 subsets that produce high levels of IL-10 and low levels of IL-12, downregulate infl ammation, and initiate tissue repair [18][19][20] . A sustained imbalance between M1 and M2 macrophages in favor of the M1 phenotype has been shown to contribute to nonhealing disorders [ 21 ] .…”

Section: Inflammation and Oxidative Stress In Chronic Woundsmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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Section: Inflammation and Oxidative Stress In Chronic Woundsmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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“…7 It is well known that macrophages respond to environmental cues by adopting either ''classically'' activated (M1) proinflammatory or ''alternatively'' activated (M2a, M2b, M2c, and M2d) wound healing phenotypes. 8,9 M2a macrophages secrete the highest levels of PDGF-B, a chemoattractant stabilizing pericytes, and also promote anastomosis of sprouting endothelial cells in vitro. 10,11 Although PDGF is synthesized, stored, and released by platelets upon activation, it is also produced by a plethora of other cells, including smooth muscle cells, activated macrophages such as alveolar macrophages, and vascular endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications

Almahrog

Radwan

El-Zehery

et al. 2016

Journal of Oral Biology and Craniofacial Research

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“…A reduced number of lymphocytes and giant cells were the reason for less local inflammatory response in both Andiroba groups (Table 2) as the lymphocytes are responsible for inflammatory response augmentation (Ferrante et al, 2012).…”

Section: Discussionmentioning

confidence: 98%

“…Andiroba oil inflammatory response modulation did not significantly interfere with fibrosis formation, which was similar in both AndG and CONT groups (Table 3). Albeit, when the herbal extract was used as a mesh coating, there were more intense fibrosis and mesh reabsorption, probably due to the greater foreign body type response (Ferrante et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Andiroba oil (Carapa guianensis) on ventral hernia repair

Yasojima

Costa²,

Houat³

et al. 2014

J. Med. Plants Res.

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In the Amazon rainforest region, Andiroba oil is an herbal oil that is widely used by the local population to treat several inflammatory diseases. The objective of this study was to test Andiroba oil as a mesh coating or by oral administration in a rat model of excisional abdominal wall defect as an alternative to modulate inflammatory response without impairing the ventral hernia repair. Thirty six animals were distributed into three groups (N=12). (1) In the control group (CONT), ventral hernia repair was done using polypropylene/polyglecaprone mesh. (2) In the Andiroba oil gavage group (AndG), animals were treated with the meshes and 0.63 ml/kg of Andiroba oil was given by oral administration for 7 days prior to the mesh placement. (3) In the Andiroba oil submersion group (AndS), animals were treated with meshes that were previously submersed in Andiroba oil. At the 7th, 14th, and 21st days, macroscopic and microscopic analyses were done. AndG had fewer adhesions, necrosis, and lymphocytes, as well as similar collagen fiber formation and fibrosis areas as CONT. AndS showed a higher number of macrophages, fibrosis area, and less collagen fiber formation. Oral administration of Andiroba oil modulated inflammatory response, reduced abdominal adhesion formation, and did not impair tissue healing.

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Regulation of Macrophage Polarization and Wound Healing

Cited by 480 publications

References 19 publications

Pathogenesis of wound healing disorders in the elderly

Pathogenesis of wound healing disorders in the elderly

In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications

Andiroba oil (Carapa guianensis) on ventral hernia repair

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