Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Baker, Phillip J.

doi:10.1128/iai.58.11.3465-3468.1990

Cited by 73 publications

(33 citation statements)

References 21 publications

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“…These cells mature slowly and maximal activity is not achieved until the age of 8-10 weeks. The T-cell activity is fully mature in 2-week-old mice [21], Thus, in young mice the T^ cells dominate, and this may in part explain why the 5-week-old mice in our study obtained lower antibody levels than 9-11-week-old mice after immunization. B cells resident in the marginal zone of the spleen respond to T-independent antigens like pneumococcal polysaccharide antigens [22].…”

Section: Discussionmentioning

confidence: 57%

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Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice

Aaberge¹,

North

Groeng³

et al. 1993

Scand J Immunol

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The anti-pneumococcal antibody response was studied in young (5-week-old) and adult (10-week-old) BALB/c and CBA/J mice and in adult (9-10-week-old) and old (12-, 18- and 24-month-old) AB6F1 and B6D2F1 mice after s.c. immunization with a 23-valent pneumococcal polysaccharide vaccine. Both young and adult mice showed a significant IgM antibody response to the vaccine 6 days after immunization with 1-11 micrograms antigen. There were significant immune responses to serotypes 1, 2, 4 and 7F in contrast to small responses to serotypes 14, 19F and 23F after immunization with the vaccine. One month after immunization, there were only marginal differences in IgM anti-pneumococcal antibody levels to the vaccine (anti-PPS) between immunized and unimmunized BALB/c mice, whereas in CBA/J mice the anti-PPS remained higher in immunized than in unimmunized mice. Immunization of old mice induced a significant IgM antibody response 6 days after immunization, but the anti-PPS thereafter decreased rapidly towards preimmunization values in AB6F1 mice. A significant IgG anti-PPS was not detected in any of the mice studied. The IgA anti-PPS tended to vary over time with no consistent pattern. It is important to carefully consider age and strain of the mice used when studying the immune response to pneumococcal polysaccharide antigens.

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Section: Discussionmentioning

confidence: 57%

“…Although pneumococcal polysaccharide antigens are Tindependent antigens, both T suppressor (T,) cells and T amplifier (T^) cells act on B cells to modulate the magnitude of the antibody response (for references see Ref. 21). Ta cells act to expand an ongoing immune response.…”

Section: Discussionmentioning

confidence: 99%

Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice

Aaberge¹,

North

Groeng³

et al. 1993

Scand J Immunol

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“…However, T lymphocytes can modulate the anti-caps-PS immune response. CD4(ϩ) T lymphocytes augment the antibody response, whereas CD8(ϩ) T lymphocytes suppress the antibody response [5]. Recently, we reported an essential role for CD40-CD40L interactions in T lymphocyte-mediated modulation of the immune response to pneumococcal caps-PS [7,8].…”

Section: Discussionmentioning

confidence: 98%

“…The previous experiments suggested a key regulatory role for CTLA-4 in the antibody response to caps-PS. As CTLA-4 is expressed in T lymphocytes, a series of experiments was performed to test whether T lymphocytes, which have been shown to be involved in the regulation of the immune response to caps-PS [5], are involved in the CTLA-4-mediated modulation of the immune response to caps-PS.…”

Section: The Role Of T Lymphocytes In the Ctla-4mediated Regulation Omentioning

confidence: 99%

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Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides

Boudewijns

Jeurissen

Wuyts

et al. 2005

Journal of Leukocyte Biology

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The capsular polysaccharides (caps-PS) of Streptococcus pneumoniae are classified as thymus-independent antigens. Nevertheless, T lymphocytes can modulate the antibody response to caps-PS. In this study, we show that anticytotoxic T lymphocyte-associated antigen 4 (CTLA-4) treatment, along with administration of caps-PS to BALB/c mice, resulted in a dose-dependent generation of a strong caps-PS-specific antibody response. Anti-CTLA-4 treatment had no effect on the immunoglobulin G (IgG) antibody production in athymic nu/nu mice. Anti-CTLA-4 treatment stimulated the IgG antibody production in severe combined immunodeficiency (SCID)/SCID mice reconstituted with CTLA-4(-/-) B lymphocytes and wild-type T lymphocytes. This excluded the possibility that anti-CTLA-4 enhanced antibody production by direct interaction with B lymphocytes. Anti-CTLA-4 treatment enhanced the antibody production in SCID/SCID mice reconstituted with B lymphocytes and CD4(+) and CD8(+) T lymphocytes but not in SCID/SCID mice reconstituted with B lymphocytes in the absence of CD4(+) and/or CD8(+) cells. Administration of anti-CTLA-4 in BALB/c mice but not in nu/nu mice resulted in a markedly increased production of interleukin (IL)-2, IL-4, and interferon-gamma. Taken together, these data strongly suggest a role of T lymphocytes and CTLA-4 in the regulation of the antibody response to caps-PS.

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T cell function in patients with impaired antibody responses to polysaccharide antigens

et al. 1991

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Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

Cited by 73 publications

References 21 publications

Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice

Antibody Response to Pneumococcal Polysaccharide Vaccine in Young, Adult and Old Mice

Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides

T cell function in patients with impaired antibody responses to polysaccharide antigens

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