2016
DOI: 10.1038/cr.2016.146
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Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

Abstract: Autophagy requires diverse membrane sources and involves membrane trafficking of mATG9, the only membrane protein in the ATG family. However, the molecular regulation of mATG9 trafficking for autophagy initiation remains unclear. Here we identified two conserved classic adaptor protein sorting signals within the cytosolic N-terminus of mATG9, which mediate trafficking of mATG9 from the plasma membrane and trans-Golgi network (TGN) via interaction with the AP1/2 complex. Src phosphorylates mATG9 at Tyr8 to main… Show more

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Cited by 166 publications
(162 citation statements)
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References 48 publications
(55 reference statements)
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“…D). To further confirm these observations, we used another mAtg9 shRNA and ATG9A KO cells , and consistent results were obtained (Fig. S2A–F).…”
Section: Resultssupporting
confidence: 72%
“…D). To further confirm these observations, we used another mAtg9 shRNA and ATG9A KO cells , and consistent results were obtained (Fig. S2A–F).…”
Section: Resultssupporting
confidence: 72%
“…162), the downstream effectors ATG9 (REF. 163), ATG14L 159 , VPS34 (also known as PI3K type 3), Beclin1 and AMBRA1 (REFS 161,164), and the trafficking protein Sec16A 165 (BOX 2, FIG. 4 and reviewed in REF.…”
Section: Ampk Regulates Autophagy and Mitophagymentioning
confidence: 99%
“…Given that both AMPK and ULK1 have been reported to directly phosphorylate distinct sites in both Beclin-1 and Vps34, much remains to be clarified about the temporal and spatial control of autophagy initiation in response to different stresses. In addition, AMPK and ULK1 have also both been reported to phosphorylate and control the localization of Atg9, a transmembrane protein involved in early autophagosome formation (Mack et al, 2012; Weerasekara et al, 2014; Zhou et al, 2017). …”
Section: Metabolic Consequences Of Ampk Activationmentioning
confidence: 99%