Regulation of Membrane Assembly During Development of Sarcoplasmic Reticulum: The Possible Role of Calcium*

Martonosi, Anthony; Dux, L.; Terjung, Ronald L.; Roufa, Dikla G.

doi:10.1111/j.1749-6632.1982.tb25771.x

Cited by 22 publications

(11 citation statements)

References 95 publications

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“…Apparently, extracellular Ca 2+ could enhance the effect of A23187, but the ionophore is effective even in Ca2÷-deficient medium. Our measurements at the mRNA levels confirmed previous GRP protein synthesis observations in cells shifted from low to normal Ca 2+ media (Martonosi et al, 1982) and in cells grown in Ca2+-deprived medium (Lamarche et al, 1985).…”

Section: Discussionsupporting

confidence: 90%

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

Resendez

Ting

Kim

et al. 1986

The Journal of Cell Biology

103

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Abstract. The calcium ionophore A23187 can reversibly induce the expression of two glucose-regulated genes, p3C5 and p4A3. This induction requires a continuous presence of the ionophore for over 2 h. Although extracellular Ca 2+ is important for the optimal effect of A23187, it is not necessary for the induction, since a similar response with a lower magnitude can be triggered in cells cultured in low Ca 2+ medium buffered with EGTA. Both the basal and induced levels of p3C5 and p4A3 transcripts can be modulated by the calmodulin antagonist W-7, indicating the involvement of CaE+/calmodulin-associated pathways. In addition, the sensitivity of the A23187 induction to cycloheximide suggests that the induction process is dependent on de novo protein synthesis.

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Section: Discussionsupporting

confidence: 90%

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

Resendez

Ting

Kim

et al. 1986

The Journal of Cell Biology

103

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“…2), suggesting that general effects caused by ionophore treatment, such as K+-H+ exchange, electrical potential, and shift in pH, were not involved. Our results confirm the previous observations that the effect of Ca2+ ionophores on GRP94 and GRP78 protein synthesis is not due to changes in the Na+ concentration of the cells or as a result of uncoupling of oxidative phosphorylation (14). transcripts is tissue specific or species specific, we treated cultures of rat kidney fibroblasts (NRK), mouse connective tissue fibroblasts (LA9), human embryo kidney cells (293), and Chinese hamster lung fibroblasts (Wg1A) with A23187.…”

Section: Resultssupporting

confidence: 77%

“…We and others have examined the pattern of protein synthesis in a variety of cells to investigate the influence of the extracellular Ca2+ concentration and of Ca2+ ionophores on the synthesis of specific proteins. Two proteins have recently been identified whose synthesis is specifically stimulated by the calcium ionophores ionomycin and A23187 (10,14,21,24). The same proteins can also be induced by shifting cells from low Ca2+ (0.15 mM) to normal Ca2+ (1.8 mM) medium (14).…”

mentioning

confidence: 99%

“…Two proteins have recently been identified whose synthesis is specifically stimulated by the calcium ionophores ionomycin and A23187 (10,14,21,24). The same proteins can also be induced by shifting cells from low Ca2+ (0.15 mM) to normal Ca2+ (1.8 mM) medium (14). These are the 94-to 100-kilodalton and 78-to 80-kilodalton proteins whose synthesis is stimulated by the absence of glucose in the culture medium; they are generally referred to as the glucose-regulated proteins (GRPs) (15,16,18).…”

mentioning

confidence: 99%

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Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes.

Resendez¹,

Attenello²,

Grafsky³

et al. 1985

Mol. Cell. Biol.

148

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Using two cDNA clones which encode hamster genes specifically induced by glucose starvation, we demonstrated that an 8- and 30-fold increase, respectively, in the transcription rates of these genes was coordinately effected by calcium ionophore A23187 treatment, resulting in a similar increase in the steady-state levels of their mRNAs. This response was observed within several hours of ionophore treatment in several mammalian cell types and appeared to be specifically mediated by A23187 but not by other ionophores in general. To define the regulatory sequence which mediates this Ca2+-induced response, we showed by gene transfection techniques that the 5' flanking sequence of a rat glucose-regulated gene contained the region for induction by A23187. The system reported here offers attractive features for the study of specific gene regulation by Ca2+.

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“…An increase in [Ca# + ] i , as well as increased expression of myogenin, have been suggested to mediate the repressing effect of continuous contractile activity on fast-muscle gene expression [12,19,[38][39][40][41]. Expression of the fast phenotype is to a large extent dependent on T $…”

Section: Discussionmentioning

confidence: 99%

Cross-talk between transcriptional regulation by thyroid hormone and myogenin: new aspects of the Ca2+-dependent expression of the fast-type sarcoplasmic reticulum Ca2+-ATPase

Thelen

Simonides

Muller

et al. 1998

Biochemical Journal

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We have previously demonstrated an interaction between the major determinants of skeletal muscle phenotype by showing that continuous contractile activity represses the thyroid hormone (3,3h,5-tri-iodothyronine ; T $ )-dependent transcriptional activity of fast-type sarcoplasmic\endoplasmic-reticulum Ca# + -ATPase (SERCA1), a characteristic of the fast phenotype. Both the free cytosolic Ca# + concentration ([Ca# + ] i ) and the myogenic determination factors MyoD and myogenin have been implicated as mediators of the effect of contractile activity on skeletal muscle phenotype. Using L6 cells we have shown that an increase in the steady-state [Ca# + ] i above the resting level of 120 nM indeed can mimic the effect of contractile activity on T $ -dependent

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Regulation of Membrane Assembly During Development of Sarcoplasmic Reticulum: The Possible Role of Calcium*

Cited by 22 publications

References 95 publications

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

Calcium ionophore A23187 as a regulator of gene expression in mammalian cells.

Calcium ionophore A23187 induces expression of glucose-regulated genes and their heterologous fusion genes.

Cross-talk between transcriptional regulation by thyroid hormone and myogenin: new aspects of the Ca2+-dependent expression of the fast-type sarcoplasmic reticulum Ca2+-ATPase

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