Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b

Chen, Lei; Liu, Xu; Wang, Gang

doi:10.1007/s13277-015-3619-4

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…The interactions were further confirmed through RT-qPCR. miR-449b is an uncommonly investigated miRNA with its roles largely unrevealed except its inhibiting roles in several cancer types [38,39]. As partially coincident with our findings, miR-449b-5p has been documented to alleviate hepatocyte injury following liver ischemia and reperfusion via targeting HMGB1 [40], indicating its role in injury alleviation.…”

Section: Discussionsupporting

confidence: 87%

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway

Gao

et al. 2021

Bioscience Reports

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Sepsis is a common cause of death of patients in intensive care unit. The study aims to figure out the role of lncRNA GAS5 in the myocardial depression in mice with sepsis. Cecal ligation and puncture (CLP) was applied to induce sepsis in mice, and then the heart function, myocardium structure, and the inflammatory response were evaluated. Differentially expressed lncRNAs in mice with sepsis were identified. Then gain- and loss-of-functions of GAS5 were performed in mice to evaluate its role in mouse myocardial depression. The lncRNA-associated miRNA-mRNA network was figured out via an integrative prediction and detection. Myocardial injury was observed by overexpression of HMGB1 in septic mice with knockdown of GAS5 expression. Activity of NF-κB signaling was evaluated, and NF-κB inhibition was induced in mice with sepsis and over-expression of GAS5. Collectively, CLP resulted in myocardial depression and injury, and increased inflammation in mice. GAS5 was highly-expressed in septic mice. GAS5 inhibition reduced myocardial depression, myocardial injury and inflammation responses in septic mice. GAS5 was identified to bind with miR-449b and to elevate HMGB1 expression, thus activating the NF-κB signaling. HMGB1 overexpression or NF-κB inactivation reduced the GAS5-induced myocardial depression and inflammation in septic mice. Our study suggested that GAS5 might promote sepsis-induced myocardial depression via the miR-449b/HMGB1 axis and the following NF-κB activation.

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Section: Discussionsupporting

confidence: 87%

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway

Gao

et al. 2021

Bioscience Reports

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“…To the best of our knowledge there was no report showing adverse effects in the GLTP gene knock-in or -out animals. The GLTP expression was regulated by miR-449b, which is one of the isoforms of miR-449 and has its function related to cell cycle, differentiation and apoptosis 35 . Also important is the good safety of bicyclol in human at the dose used in the study.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication

Huang

Xue

et al. 2019

Acta Pharmaceutica Sinica B

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Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus (HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein (GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A (VAP-A) in competition with the HCV NS5A, causing an interruption of the complex formation between VAP-A and HCV NS5A. As the formation of VAP-A/NS5A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents (DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication.

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“…This is just the opposite in the “CancerG” level where one PCG was influenced by several lncRNAs, suggesting key roles of those 42 cancer PCGs in THCA (42 PCGs are listed in Supplementary Table 4 ). For example, ENSG00000105976 (c-Met) is an oncogene protein with tyrosine kinase activity, and its abnormal activation has been detected in various cancers, including THCA [ 36 , 37 ]. Another example is that ENSG00000066468 (FGFR-2), which has been implicated in the onset of THCA, was reduced in THCA [ 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Identification of novel diagnostic biomarkers for thyroid carcinoma

et al. 2017

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Thyroid carcinoma (THCA) is the most universal endocrine malignancy worldwide. Unfortunately, a limited number of large-scale analyses have been performed to identify biomarkers for THCA. Here, we conducted a meta-analysis using 505 THCA patients and 59 normal controls from The Cancer Genome Atlas. After identifying differentially expressed long non-coding RNA (lncRNA) and protein coding genes (PCG), we found vast difference in various lncRNA-PCG co-expressed pairs in THCA. A dysregulation network with scale-free topology was constructed. Four molecules (LA16c-380H5.2, RP11-203J24.8, MLF1 and SDC4) could potentially serve as diagnostic biomarkers of THCA with high sensitivity and specificity. We further represent a diagnostic panel with expression cutoff values. Our results demonstrate the potential application of those four molecules as novel independent biomarkers for THCA diagnosis.

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Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b

Cited by 9 publications

References 29 publications

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway

Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication

Identification of novel diagnostic biomarkers for thyroid carcinoma

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