Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing

Zha, Kangkang; Tan, Meijun; Hu, Yiqiang; Hu, Weixian; Zhang, Shengming; Zhao, Yanzhi; Lin, Ze; Zhang, Wenqian; Xue, Hang; Mi, Bobin; Zhou, Wu; Feng, Qian; Cao, Faqi; Liu, Guohui

doi:10.1016/j.bioactmat.2024.03.025

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.03.025

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Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing

Kangkang Zha,

Meijun Tan,

Yiqiang Hu

et al.

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Cited by 2 publications

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Wang,

Zeng,

Gan

et al. 2024

Nano-Micro Lett.

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Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Wang,

Zeng,

Gan

et al. 2024

Nano-Micro Lett.

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Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

Yu,

Xiao,

Guan

et al. 2024

Front. Mol. Biosci.

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Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that chondrocyte ferroptosis plays a role in OA development. However, most research has concentrated on ferroptosis regulation involving typical iron ions, potentially neglecting the significance of elevated copper ions in both serum and joint fluid of patients with OA. This review aims to fill this gap by systematically examining the interplay between copper metabolism, oxidative stress, ferroptosis, and copper-associated cell death in OA. It will provide a comprehensive overview of copper ions’ role in regulating ferroptosis and their dual role in OA. This approach seeks to offer new insights for further research, prevention, and treatment of OA.

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Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing

Cited by 2 publications

References 50 publications

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

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