Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational association

Javaid, Anam; Zahra, Duaa; Rashid, Fatima; Mashraqi, Mutaib M.; Alzamami, Ahmad; Khurshid, Mohsin; Ashfaq, Usman Ali

doi:10.1016/j.sjbs.2022.03.005

Cited by 9 publications

(6 citation statements)

References 103 publications

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“…Moreover, excluding MYC-amplified tumors from the differential expression analysis, confirmed the altered pattern of expression observed with the complete cohort. We may therefore hypothesize that the dysregulation of the observed miRNAs could be due to alternative underlying mechanisms other than amplification, such as epigenetic effects (including methylation or histone modification 45 ) or the presence of genetic variants that could work as expression quantitative loci for miRNAs. 46,47 To further investigate the possible targets of the differentially expressed miRNAs in CRC tissues, we retrieved all their experimentally validated targets from miRWalk database.…”

Section: Discussionmentioning

confidence: 99%

The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients

et al. 2022

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Section: Discussionmentioning

confidence: 99%

The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients

et al. 2022

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“…Although the specific regulatory mechanisms remain unpredictable, it has become distinct that plant‐derived natural products regulate epigenetic events in human health. Mounting evidence indicates that plant‐derived natural products demonstrate their antitumor efficacy through epigenetic regulation such as DNA methylation, histone modification, and non‐coding RNA (ncRNA) expression (Javaid et al, 2022; Maemoto et al, 2021).…”

Section: Antitumor Effect Of Natural Productsmentioning

confidence: 99%

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Zhang,

Wang,

Qin

et al. 2024

Phytotherapy Research

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Cancer is a highly heterogeneous disease that poses a serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, the prognosis and survival rate of cancer remain poor due to late diagnosis, drug resistance, and adverse reactions. Therefore, it is very necessary to study the development mechanism of cancer and formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by targeting abnormal epigenetic changes. The main active part of garlic is organic sulfur compounds, of which diallyl trisulfide (DATS) content is the highest, accounting for more than 40% of the total composition. The garlic‐derived compounds have been recognized as an antioxidant for cancer prevention and treatment. However, the molecular mechanism of the antitumor effect of garlic‐derived compounds remains unclear. Recent studies have identified garlic‐derived compound DATS that plays critical roles in enhancing CpG demethylation or promoting histone acetylation as an epigenetic inhibitor. Here, we review the therapeutic progress of garlic‐derived compounds against cancer through epigenetic pathways.

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“…Tumor initiation, progression and metastasis are influenced by genetic and epigenetic factors [ 86 ], CSCs, and the dynamic crosstalk between CSCs, cancer cells and other TME components [ 87 ] ( Figure 3 ). The TME is a dynamic network comprising cellular and non-cellular components, which orchestrate tumor growth, metastasis, and treatment resistance.…”

Section: The Tumor Microenvironment and Its Role In Tumor Recurrence ...mentioning

confidence: 99%

Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment

et al. 2022

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Cancer metastasis and treatment resistance are the main causes of treatment failure and cancer-related deaths. Their underlying mechanisms remain to be fully elucidated and have been attributed to the presence of cancer stem cells (CSCs)—a small population of highly tumorigenic cancer cells with pluripotency and self-renewal properties, at the apex of a cellular hierarchy. CSCs drive metastasis and treatment resistance and are sustained by a dynamic tumor microenvironment (TME). Numerous pathways mediate communication between CSCs and/or the surrounding TME. These include a paracrine renin-angiotensin system and its convergent signaling pathways, the immune system, and other signaling pathways including the Notch, Wnt/β-catenin, and Sonic Hedgehog pathways. Appreciation of the mechanisms underlying metastasis and treatment resistance, and the pathways that regulate CSCs and the TME, is essential for developing a durable treatment for cancer. Pre-clinical and clinical studies exploring single-point modulation of the pathways regulating CSCs and the surrounding TME, have yielded partial and sometimes negative results. This may be explained by the presence of uninhibited alternative signaling pathways. An effective treatment of cancer may require a multi-target strategy with multi-step inhibition of signaling pathways that regulate CSCs and the TME, in lieu of the long-standing pursuit of a ‘silver-bullet’ single-target approach.

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Regulation of micro-RNA, epigenetic factor by natural products for the treatment of cancers: Mechanistic insight and translational association

Cited by 9 publications

References 103 publications

The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients

The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment

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