2005
DOI: 10.1091/mbc.e04-03-0260
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Regulation of Microtubule-dependent Recycling at theTrans-Golgi Network by Rab6A and Rab6A'

Abstract: The small GTPase rab6A but not the isoform rab6A has previously been identified as a regulator of the COPIindependent recycling route that carries Golgi-resident proteins and certain toxins from the Golgi to the endoplasmic reticulum (ER). The isoform rab6A has been implicated in Golgi-to-endosomal recycling. Because rab6A but not A , binds rabkinesin6, this motor protein is proposed to mediate COPI-independent recycling. We show here that both rab6A and rab6A GTP-restricted mutants promote, with similar effic… Show more

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Cited by 105 publications
(150 citation statements)
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References 68 publications
(89 reference statements)
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“…S6 in the supplementary material, and data not shown). These results are consistent with the characterized role of mammalian Rab6 in the trafficking of Golgiderived membranes (Antony et al, 1992;Martinez et al, 1994;Matanis et al, 2002;Short et al, 2002;White et al, 1999;Young et al, 2005).…”
Section: Fig 3 Trafficking Of Yolkless and Gurken Is Impaired In Rasupporting
confidence: 89%
See 1 more Smart Citation
“…S6 in the supplementary material, and data not shown). These results are consistent with the characterized role of mammalian Rab6 in the trafficking of Golgiderived membranes (Antony et al, 1992;Martinez et al, 1994;Matanis et al, 2002;Short et al, 2002;White et al, 1999;Young et al, 2005).…”
Section: Fig 3 Trafficking Of Yolkless and Gurken Is Impaired In Rasupporting
confidence: 89%
“…Finally, RAB6a, RAB6aЈ, BICD2 and Dynactin appear to cooperate to mediate the recycling and retrograde transport of proteins from the TGN (Young et al, 2005), indicating that, in mammals, these three proteins are physically and functionally linked.…”
Section: Introductionmentioning
confidence: 99%
“…After 2 weeks, GFPor mCherry-positive colonies were selected. siRNAs were directed against the following target sites: siRNA1 against ARHGEF10, 5′-GGAAACTA-TCAGAACTTAA-3′; siRNA2 against ARHGEF10, 5′-GCAGAGAAGT-TAAATGAAA-3′; siRab6, 5′-GACATCTTTGATCACCAGA-3′ (Young et al, 2005); siRab8, 5′-GGAAAGCACAAATGAAGGA-3′ (Grigoriev et al, 2011). Non-targeting control siRNA was selected as a random sequence, 5′-ACACCGAAUAACUUUAACCTT-3′ and 5′-GGUUAAA-GU UAUUCGGUGUTT-3′.…”
Section: Constructsmentioning
confidence: 99%
“…To cite a few, transport between the ER and Golgi complex is regulated by Rab1 and Rab2 which orchestrate specificity in fusion with membranes at the cisGolgi (4 -6). At the level of the Golgi complex, Rab6a regulates trafficking in both a retrograde (from early endosomes and Golgi to the ER) and an anterograde (from the Golgi to the plasma membrane) direction (7)(8)(9)(10)(11)(12)(13). Transport from the Golgi to the plasma membrane can follow several paths.…”
Section: Previous Reports By Us and Others Demonstrated That G Proteimentioning
confidence: 99%