Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment

Bowne-Anderson, Hugo; Hibbel, Anneke; Howard, Jonathon

doi:10.1016/j.tcb.2015.08.009

Cited by 92 publications

(79 citation statements)

References 104 publications

(120 reference statements)

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“…However, the molecular events that cause loss of the cap during otherwise steady-state growth are poorly understood (Gardner et al. , 2013; Bowne-Anderson et al. , 2015; Brouhard, 2015).…”

Section: Discussionmentioning

confidence: 99%

GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe

Piedra

Kim

Garza

et al. 2016

MBoC

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“…However, the molecular events that cause loss of the cap during otherwise steady-state growth are poorly understood (Gardner et al. , 2013; Bowne-Anderson et al. , 2015; Brouhard, 2015).…”

Section: Discussionmentioning

confidence: 99%

GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe

Piedra

Kim

Garza

et al. 2016

MBoC

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“…Although MT dynamic instability is stochastic, it is regulated by many MT-associated proteins (MAPs). Different MAPs can either stabilize or destabilize MTs and help convert growing MTs into shrinking MTs (catastrophe) or visa versa (rescue; Akhmanova and Steinmetz, 2015; Bowne-Anderson et al , 2015). Of importance, MTs also serve as the primary substrate for trafficking material throughout the cell.…”

Section: Dynamic Microtubules In Neuronal Dendritesmentioning

confidence: 99%

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

Dent

2017

MBoC

119

104

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Microtubules (MTs) are cytoskeletal polymers composed of repeating subunits of tubulin that are ubiquitously expressed in eukaryotic cells. They undergo a stochastic process of polymerization and depolymerization from their plus ends termed dynamic instability. MT dynamics is an ongoing process in all cell types and has been the target for the development of several useful anticancer drugs, which compromise rapidly dividing cells. Recent studies also suggest that MT dynamics may be particularly important in neurons, which develop a highly polarized morphology, consisting of a single axon and multiple dendrites that persist throughout adulthood. MTs are especially dynamic in dendrites and have recently been shown to polymerize directly into dendritic spines, the postsynaptic compartment of excitatory neurons in the CNS. These transient polymerization events into dendritic spines have been demonstrated to play important roles in synaptic plasticity in cultured neurons. Recent studies also suggest that MT dynamics in the adult brain function in the essential process of learning and memory and may be compromised in degenerative diseases, such as Alzheimer’s disease. This raises the possibility of targeting MT dynamics in the design of new therapeutic agents.

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“…The two actin nucleation protein complexes, namely, the Arp2/3 complex and formin 1 (or the spire/formin complex) that induce branched actin polymerization and linear actin filament polymerization, respectively, are working in concert with other actin regulatory proteins (e.g., actin-bundling proteins, cleavage and depolymerization proteins) to confer the plasticity of F-actin network in the Sertoli cell. On the other hand, MTs are also modulated by other MT-binding/regulatory proteins, such as EB1 which is known to induce MT stabilization [82–84]. However, formin 1, an actin nucleation protein, is also recently shown to modulate Sertoli cell MT organization, illustrating these two cytoskeletons are intimately engaged in the testis to support BTB dynamics during spermatogenesis.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons

Wen

Tang

et al. 2018

Methods in Molecular Biology

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The blood-testis barrier (BTB) is an important ultrastructure in the testis that supports meiosis and postmeiotic spermatid development since a delay in the establishment of a functional Sertoli cell barrier during postnatal development in rats or mice by 17–20 day postpartum (dpp) would lead to a delay of the first wave of meiosis. Furthermore, irreversible disruption of the BTB by toxicants also induces infertility in rodents. Herein, we summarize recent findings that BTB dynamics (i.e., disassembly, reassembly, and stabilization) are supported by the concerted efforts of the actin- and microtubule (MT)-based cytoskeletons. We focus on the role of two actin nucleation protein complexes, namely, the Arp2/3 (actin-related protein 2/3) complex and formin 1 (or the formin 1/spire 1 complex) known to induce actin nucleation, respectively, by conferring plasticity to actin cytoskeleton. We also focus on the MT plus (+)-end tracking protein (+TIP) EB1 (end-binding protein 1) which is known to confer MT stabilization. Furthermore, we discuss in particular how the interactions of these proteins modulate BTB dynamics during spermatogenesis. These findings also yield a novel hypothetical concept regarding the molecular mechanism that modulates BTB function.

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Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment

Cited by 92 publications

References 104 publications

GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe

GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons

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