1992
DOI: 10.1002/neu.480230910
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Regulation of motoneuron death in the spinal nucleus of the bulbocavernsus

Abstract: A sexual dimorphism in the number of motoneurons in the spinal nucleus of the bulbocavernosus (SNB) of rats is engendered by a sex difference in ontogenetic cell death. Testicular secretions, specifically androgenic steroids, reduce SNB motoneuron death in males. The fate of the target muscles generally mirrors that of the motoneurons, and androgens appear to exert their effects upon the target muscles, sparing the motoneurons as a secondary consequence. Treatment with ciliary neurotrophic factor can also spar… Show more

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Cited by 48 publications
(34 citation statements)
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“…The presence of both the BC and LA muscles in male gerbils at birth is consistent with findings in newborn rats and mice (C ihá k et al, 1970;Breedlove and Arnold, 1983b;Forger et al, 1992;Park et al, 1999). Compared with the LA muscles of male rats, the BC muscles of male gerbils grew more slowly in the early postnatal period.…”
Section: Normal Ontogeny Of Bc and La Musclessupporting
confidence: 85%
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“…The presence of both the BC and LA muscles in male gerbils at birth is consistent with findings in newborn rats and mice (C ihá k et al, 1970;Breedlove and Arnold, 1983b;Forger et al, 1992;Park et al, 1999). Compared with the LA muscles of male rats, the BC muscles of male gerbils grew more slowly in the early postnatal period.…”
Section: Normal Ontogeny Of Bc and La Musclessupporting
confidence: 85%
“…Sexual dimorphism is evident throughout the muscular and nervous systems of most mammals, most notably in structures involved in reproductive behaviors (Jordan et al, 1990;Forger et al, 1992;Joubert et al, 1994;Cooke et al, 1998). In many instances, the presence of gonadal steroids during specific periods of life is responsible for the induction of this sexual dimorphism (Breedlove, 1986(Breedlove, , 1992.…”
mentioning
confidence: 99%
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“…In extreme cases, such as the motor nucleus (SNB) innervating the levator ani/bulbocavernosus muscles of male rats or the telencephalic nucleus X of song birds, a structure that is robust in the male is barely detectable in the female. The origin of the dramatic sex difference in the SNB probably results from androgen regulated prevention of ontogenetic cell death in males (reviewed in Forger et al, 1992).…”
Section: Discussionmentioning
confidence: 99%