1996
DOI: 10.1177/00220345960750011001
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Regulation of Mucous Acinar Exocrine Secretion with Age

Abstract: Denny and co-workers (Navazesh et al., 1992) recently reported decreased concentrations of MG1 and MG2 mucins in resting and stimulated whole human saliva with age. The current study was therefore conducted to examine whether there is a corresponding attenuation with age in stimulus secretion coupling regulating mucous cell exocrine secretion. We utilized an in vitro model system, isolated rat sublingual acini, to evaluate the regulation of mucous cell exocrine secretion. Rat sublingual glands are similar to h… Show more

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Cited by 15 publications
(3 citation statements)
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“…The appearance of the peptide‐stimulated mucous cells was similar to that in response to carbachol, also previously described in the human submandibular gland (Riva et al , ). Thus, humans belong to those species (rat, cat, dog, ferret, pig, sheep, mink and calf) in which VIP causes the acinar cells of salivary glands to lose secretory granules and to release proteins/glycoproteins, and when administered in vivo , during ongoing secretion, causes the flow rate to accelerate and the salivary protein concentration to increase (Lundberg et al , ; Inoue and Kanno, ; Reid and Heywood, ; Reid and Titchen, ; Bobyock and Chernick, ; Ekström and Tobin, , ; Tobin et al , ; Turner and Camden, ; Ekström et al , ; Culp and Richardson, ; Calvert et al , ; Ekström and Ekström, , ). So far, the rat and the mink are the only species where VIP per se , in addition, has been found to evoke an overt flow of saliva (Ekström et al , ; Tobin and Ekström, ).…”
Section: Discussionmentioning
confidence: 99%
“…The appearance of the peptide‐stimulated mucous cells was similar to that in response to carbachol, also previously described in the human submandibular gland (Riva et al , ). Thus, humans belong to those species (rat, cat, dog, ferret, pig, sheep, mink and calf) in which VIP causes the acinar cells of salivary glands to lose secretory granules and to release proteins/glycoproteins, and when administered in vivo , during ongoing secretion, causes the flow rate to accelerate and the salivary protein concentration to increase (Lundberg et al , ; Inoue and Kanno, ; Reid and Heywood, ; Reid and Titchen, ; Bobyock and Chernick, ; Ekström and Tobin, , ; Tobin et al , ; Turner and Camden, ; Ekström et al , ; Culp and Richardson, ; Calvert et al , ; Ekström and Ekström, , ). So far, the rat and the mink are the only species where VIP per se , in addition, has been found to evoke an overt flow of saliva (Ekström et al , ; Tobin and Ekström, ).…”
Section: Discussionmentioning
confidence: 99%
“…The pelleted chromatin samples were collected and resuspended in 1Â SDS-PAGE loading dye. All samples were electrophoresed in 18% SDS gels for 2 h at 150 V. The gels were Coomassie-stained followed by a brief silver-staining enhancement (30) to compare the ratio of the core histones.…”
Section: Precipitation Of Mg 2þ -Dependent Nucleosomal Arraysmentioning
confidence: 99%
“…VIP was subsequently found to be co-released with acetylcholine from parasympathetic nerves and was later identified in the nervous system and endocrine systems acting as a neurotransmitter/neuromodulator (Strand, 1999, Culp andRichardson, 1996). VIP is a member of a group of regulatory peptides that include secretin and glucagon among others.…”
Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning
confidence: 99%