2010
DOI: 10.1038/ncb2019
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Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA

Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immune deficiency syndrome related malignancies including Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman’s disease1. Control of viral lytic replication is essential for KSHV latency, evasion of host immune system, and induction of tumors1. Here, we show that deletion of a cluster of 14 microRNAs (miRs) from KSHV genome significantly enhances viral lytic replication as a result o… Show more

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Cited by 247 publications
(294 citation statements)
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References 39 publications
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“…Moreover, several Kaposi sarcoma herpesvirus miRNAs are vital for directly and indirectly controlling lytic transcript expression (22)(23)(24). Whereas previous studies have described the polyomavirus miRNAs as being expressed late during infection (9,12), our data show that the miRNA is expressed before the onset of DNA replication.…”
Section: Discussioncontrasting
confidence: 52%
“…Moreover, several Kaposi sarcoma herpesvirus miRNAs are vital for directly and indirectly controlling lytic transcript expression (22)(23)(24). Whereas previous studies have described the polyomavirus miRNAs as being expressed late during infection (9,12), our data show that the miRNA is expressed before the onset of DNA replication.…”
Section: Discussioncontrasting
confidence: 52%
“…mRNA quantification: Similar as miRNA quantification, except that cDNA is reverse transcribed using oligo(dT) 18 primer. The primers used are listed in supplementary information, Table S1.…”
Section: Qrt-pcrmentioning
confidence: 99%
“…Chromatin remodeling of the RTA promoter also plays a role in the regulation of KSHV reactivation (48). Recently, several studies showed that KSHV-encoded microRNAs (miRNAs) also regulate KSHV reactivation (2,42,47), further highlighting the importance of the regulation of KSHV latency and reactivation. Several cellular factors, such as XBP-1, Ras, Ets-1, PARP-1, hKFC, CBP, the SWI/SNF chromatin remodeling complex, the TRAP/Mediator complex, RBP-J, human Notch intracellular domain, and HMGB1, have been shown to promote KSHV reactivation and/or lytic gene expression (11,31,32,44,71,72,75,76), suggesting a close link between many cellular processes and KSHV reactivation.…”
mentioning
confidence: 99%