Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Shi, Hongmei; He, Yang; Li, Xuzhen; Du, Yanli; Zhao, Jinbo; Ge, Chao

doi:10.3390/genes13061033

Cited by 14 publications

(7 citation statements)

References 134 publications

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“…LncRNA is a new type of regulatory RNA, which is a ncRNA with a length of more than 200 bp. LncRNA is an important component of ncRNA ( Shi et al, 2022 ), and it plays an essential role in goat ovulation and kidding mainly by regulating transcription and post-transcription ( Lian et al, 2020 ). LncRNA also plays an important role in the regulation of the fertility network.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Mao,

Dong,

Hou

et al. 2023

Front. Genet.

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The pituitary gland serves as the central endocrine regulator of growth, reproduction, and metabolism and plays a crucial role in the reproductive process of female animals. Transcriptome analysis was conducted using pituitary gland samples from Leizhou goats with varying levels of fecundity to investigate the effects of long noncoding RNA (lncRNA), circular RNA (circRNA), and mRNA regulation on pituitary hormone secretion and its association with goat fecundity. The analysis aimed to identify lncRNAs, circRNAs, and mRNAs that influence the fertility of Leizhou goats. GO and KEGG enrichment analyses were performed on differentially expressed lncRNAs, circRNAs, and mRNAs and revealed considerable enrichment in pathways, such as regulation of hormone secretion, germ cell development, and gonadotropin-releasing hormone secretion. The pituitary lncRNAs (ENSCHIT00000010293, ENSCHIT00000010304, ENSCHIT00000010306, ENSCHIT00000010290, ENSCHIT00000010298, ENSCHIT00000006769, ENSCHIT00000006767, ENSCHIT00000006921, and ENSCHIT00000001330) and circRNAs (chicirc_029285, chicirc_026618, chicirc_129655, chicirc_018248, chicirc_122554, chicirc_087101, and chicirc_078945) identified as differentially expressed regulated hormone secretion in the pituitary through their respective host genes. Additionally, differential mRNAs (GABBR2, SYCP1, HNF4A, CBLN1, and CDKN1A) influenced goat fecundity by affecting hormone secretion in the pituitary gland. These findings contribute to the understanding of the molecular mechanisms underlying pituitary regulation of fecundity in Leizhou goats.

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Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Mao,

Dong,

Hou

et al. 2023

Front. Genet.

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“…In addition, many target mRNAs of DE lncRNAs were enriched in GO terms such as myofibril assembly, muscle fiber development, striated muscle contraction, M band, and muscle cell development. Many target mRNAs of DE miRNAs were enriched in the GO terms related to morphogenesis; the reason could be that during embryonic muscle development, the myogenic progenitor cells derived from the myotome continue to migrate and proliferate to the limbs, thereby promoting limb morphogenesis ( Shi et al, 2022 ). These results suggested that the muscle had changed dramatically at E14 compared to E10 after continuous growth and development.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of mRNAs, lncRNAs, and miRNAs in the skeletal muscle of Tibetan chickens at different developmental stages

Chen

Zhao

et al. 2023

Front. Physiol.

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Introduction: As a valuable genetic resource, native birds can contribute to the sustainable development of animal production. Tibetan chickens, known for their special flavor, are one of the important local poultry breeds in the Qinghai–Tibet Plateau. However, Tibetan chickens have a slow growth rate and poor carcass traits compared with broilers. Although most of the research on Tibetan chickens focused on their hypoxic adaptation, there were fewer studies related to skeletal muscle development.Methods: Here, we performed the transcriptional sequencing of leg muscles from Tibetan chicken embryos at E (embryonic)10, E14, and E18.Results: In total, 1,600, 4,610, and 2,166 DE (differentially expressed) mRNAs, 210, 573, and 234 DE lncRNAs (long non-coding RNAs), and 52, 137, and 33 DE miRNAs (microRNAs) were detected between E10 and E14, E10 and E18, and E14 and E18, respectively. Functional prediction showed several DE mRNAs and the target mRNAs of DE lncRNAs and DE miRNAs were significantly enriched in sarcomere organization, actin cytoskeleton organization, myofibril, muscle fiber development, and other terms and pathways related to muscle growth and development. Finally, a lncRNA–miRNA–mRNA ceRNA (competing endogenous RNA) network associated with muscle growth and development, which contained 6 DE lncRNAs, 13 DE miRNAs, and 50 DE mRNAs, was constructed based on the screened DE RNAs by Gene Ontology (GO) enrichment. These DE RNAs may play a critical regulatory role in the skeletal muscle development of chickens.Discussion: The results provide a genomic resource for mRNAs, lncRNAs, and miRNAs potentially involved in the skeletal muscle development of chickens, which lay the foundation for further studies of the molecular mechanisms underlying skeletal muscle growth and development in Tibetan chickens.

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“…Based on their length, function, and structural characteristics, ncRNAs can be divided into microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and others (Hombach and Kretz, 2016). Currently, an increasing number of studies have demonstrated the close relationship between miRNAs and lncRNAs in the development process of poultry skeletal muscle, including myoblast proliferation, differentiation, apoptosis, as well as myofiber maturation and hypertrophy (Li et al, 2016;Shi et al, 2022). Additionally, more attention has been paid to the competing endogenous RNA (ceRNA) hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNA regulation of Magang geese skeletal muscle maturation via the MAPK signaling pathway

Hong,

Xu,

et al. 2024

Front. Physiol.

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Skeletal muscle is a critical component of goose meat and a significant economic trait of geese. The regulatory roles of miRNAs and lncRNAs in the maturation stage of goose skeletal muscle are still unclear. Therefore, this study conducted experiments on the leg muscles of Magang geese at two stages: 3-day post-hatch (P3) and 3 months (M3). Morphological observations revealed that from P3 to M3, muscle fibers mainly underwent hypertrophy and maturation. The muscle fibers became thicker, nuclear density decreased, and nuclei moved towards the fiber edges. Additionally, this study analyzed the expression profiles of lncRNAs, miRNAs, and mRNAs during the skeletal muscle fiber maturation stage, identifying 1,949 differentially expressed mRNAs (DEMs), 21 differentially expressed miRNAs (DEMIs), and 172 differentially expressed lncRNAs (DELs). Furthermore, we performed enrichment analyses on DEMs, cis-regulatory genes of DELs, and target DEMs of DEMIs, revealing significant enrichment of signaling pathways including MAPK, PPAR, and mTOR signaling pathways. Among these, the MAPK signaling pathway was the only pathway enriched across all three types of differentially expressed RNAs, indicating its potentially more significant role in skeletal muscle maturation. Finally, this study integrated the targeting relationships between DELs, DEMs, and DEMIs from these two stages to construct a ceRNA regulatory network. These findings unveil the potential functions and mechanisms of lncRNAs and miRNAs in the growth and development of goose skeletal muscle and provide valuable references for further exploration of the mechanism underlying the maturation of Magang geese leg muscle.

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Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Cited by 14 publications

References 134 publications

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Transcriptome analysis of mRNAs, lncRNAs, and miRNAs in the skeletal muscle of Tibetan chickens at different developmental stages

Non-coding RNA regulation of Magang geese skeletal muscle maturation via the MAPK signaling pathway

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