Regulation of NucB2/Nesfatin-1 throughout rat pregnancy

Garcés, María Fernanda; Poveda, Natalia E.; Sánchez, Elizabeth; Sánchez, Ángel Y.; Bravo, Susana B.; Vázquez, María J.; Diéguez, Carlos; Nogueiras, Rubén; Caminos, Jorge Eduardo

doi:10.1016/j.physbeh.2014.05.042

Cited by 17 publications

(13 citation statements)

References 32 publications

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“… 81 Expression level of nesfatin-1 decreased significantly in pregnant rats, indicating the important role of nesfatin-1 in pregnancy and fetal development. 82 Detailed study showed that serum levels of nesfatin-1 were negatively correlated with levels of IL-17A in both normal pregnancy and abortion model mice. 83 IL-17A is a landmark cytokine secreted by the helper T cell subset Th17 cells, which plays an important role in the pathogenesis of inflammation, autoimmune diseases, and allogeneic organ rejection.…”

Section: Antioxidant Anti-inflammatory and Anti-apoptotic Activitiementioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Antioxidant Anti-inflammatory and Anti-apoptotic Activitiementioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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“…Nesfatin-1 and its binding sites are expressed in the female mouse reproductive organs ( Kim et al, 2010 ; Kim et al, 2011 ). Recently, it has been reported that nesfatin-1 expression levels are decreased significantly during pregnancy progresses in rat, suggesting that nesfatin-1 may play an important role during pregnancy and fetal development ( Garces et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Th 17 Cells and Nesfatin-1 are associated with Spontaneous Abortion in the CBA/j × DBA/2 Mouse Model

Chung¹,

Kim²,

Im³

et al. 2015

Development &Amp; Reproduction

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The pregnancy and abortion process involves a complex mechanism with various immune cells present in the implantation sites and several hormones associated with pregnancy, such as leptin, ghrelin and nesfatin-1. However, the mechanism underlying spontaneous abortion by maternal T helper 17 (Th17) present in the implantation sites and nesfatin-1, which is of anorexigenic hormones, is not fully understood so far. Therefore, the purpose of this study was to examine the possible roles of Th17 cells present in the implantation sites and nesfatin-1 expressed in the uterus on spontaneous abortion using the CBA/j × DBA/2 mouse model. Th17 transcription factor, ROR-γt mRNA expression was significantly increased in the abortion sites compared with the implantation sites of abortion model mice on day 14.5 and 19.5 of pregnancy. In addition, the expression levels of IL-17A mRNA were significantly higher in abortion sites than in implantation sites on day 14.5 and 19.5. Moreover, the nesfatin-1/NUCB2 protein and mRNA levels were increased in abortion sites compared with levels in implantation sites of both normal pregnant and abortion model mice on day 14.5 of pregnancy. Interestingly, nesfatin- 1/NUCB2 serum levels were not changed throughout the whole pregnancy in abortion model mice, but its serum level was dramatically increased on day 14.5, and then rapidly decreased on day 19.5 in normal pregnant mice. In this study, we showed for the first time the expression of nesfatin-1/NUCB2 mRNA and protein in implantation sites during pregnancy. The present results suggest that Th17 cells in the uterus may play an important role in the period of implantation and for maintenance of pregnancy. Furthermore, the present results suggest that Th17 cells in implantation sites may be a key regulator for maintenance of pregnancy and provides evidence that activation of these cells may be regulated by nesfatin-1/NUCB2. Further study is needed to elucidate the role of nesfatin-1 expressed in the uterus during pregnancy.

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“…This would suggest that the adult gonadotropic axis can also respond to the stimulatory effects of nesfatin-1, although its sensitivity is lower 17 . 17-estradiol and progesterone may regulate Nucb2 mRNA expression in the pituitary gland 18 . Moreover, Nucb2 mRNA expression has been found in rat, mouse, and human testes.…”

Section: Discussionmentioning

confidence: 99%

Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

Batura‐Gabryel

Bromińska

Sawicka‐Gutaj

et al. 2019

Sci Rep

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There is growing evidence that obstructive sleep apnoea (OSA) influences the hypothalamic–pituitary–gonadal axis (HPG axis) in men. The aim of the study was to assess the association of nesfatin-1 with HPG axis disturbances in OSA. This is a prospective study with consecutive enrolment. It comprises 72 newly diagnosed OSA patients ((AHI: apnoea-hypopnea index) 18 subjects: 5 ≤ AHI < 15; 24: 15 ≤ AHI < 30; 30: AHI ≥ 30) and a control group composed of 19 patients (AHI < 5). All patients underwent polysomnography and fasting blood collection for nesfatin-1, testosterone, luteinising hormone (LH), high-sensitivity C-reactive protein (hsCRP), aspartate transaminase (AST), alanine aminotransferase (ALT), creatinine and glucose. Groups had similar levels of LH, nesfatin-1 and testosterone (p = 0.87; p = 0.24; p = 0.08). Nesfatin-1 was not correlated to LH (p = 0.71), testosterone (p = 0.38), AHI (p = 0.34) or the oxygen desaturation index (ODI) (p = 0.69) either in the whole group, or in sub-groups. The study did not reveal any association between the HPG axis and nesfatin-1 in OSA adult males. It is possible that nesfatin-1 is not a mediator of HPG axis disturbances in adult patients with OSA.

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Regulation of NucB2/Nesfatin-1 throughout rat pregnancy

Cited by 17 publications

References 32 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Th 17 Cells and Nesfatin-1 are associated with Spontaneous Abortion in the CBA/j × DBA/2 Mouse Model

Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

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