Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Mirzaei, Sepideh; Zarrabi, Ali; Hashemi, Farid; Zabolian, Amirhossein; Saleki, Hossein; Ranjbar, Adnan; Saleh, Seyed Hesam Seyed; Bagherian, Morteza; Sharifzadeh, Seyed Omid; Hushmandi, Kiavash; Líšková, Alena; Kubatka, Peter; Makvandi, Pooyan; Tergaonkar, Vinay; Kumar, Alan Prem; Ashrafizadeh, Milad; Sethi, Gautam

doi:10.1016/j.canlet.2021.03.025

Cited by 187 publications

(114 citation statements)

References 275 publications

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“…These non-coding RNAs (ncRNAs) have 19–24 nucleotides in length and can regulate gene expression at post-transcriptional level. 172 , 173 The miRNAs are able to decrease expression level of target gene by binding to 3 / -untranslated region (3 / -UTR). Sometimes, miRNAs bind to 5 / -UTR and increase expression of target genes.…”

Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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“…The field of cancer chemotherapy is suffering from a number of challenges; drug resistance is the most significant. In respect to the benefits of chemotherapy in the treatment of cancer patients, factors responsible for mediating chemoresistance should be identified in further studies, in order to prevent drug resistance [1][2][3][4][5][6][7]. Cisplatin (CP) is a platinumcontaining drug that was first discovered in 1965 and became famous due to its great antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

et al. 2021

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The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS in cancer as a pro-survival or pro-death mechanism, ROS can result in CP resistance. In the present review, association of ROS with CP sensitivity/resistance is discussed, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy. Furthermore, anti-tumor compounds, such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described. Nanoparticles can provide co-delivery of CP with anti-tumor agents and by mediating photodynamic therapy, and induce ROS overgeneration to trigger CP sensitivity. Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1α and Nrf2 to promote ROS levels, leading to CP sensitivity. Considering the relationship between ROS and CP chemotherapy, and translating these findings to clinic can pave the way for effective treatment of cancer patients.

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“…Increasing lncRNAs have been found to be involved in the prevalent ceRNA networks, where they could compete with the upstream mediators of mRNAs, miRNAs, for the 3’UTR region of mRNAs, consequently regulating such mRNAs [ 27 , 28 ]. MiRNAs are a group of endogenous small ncRNAs that can modulate target gene expression at post-transcriptional level and capable of interaction with mRNA-coding genes [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297

Liu

et al. 2021

Diagn Pathol

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Background Cervical cancer (CC) endangers women’s health in the world range. Accumulating studies have revealed the crucial regulatory role of long non-coding RNAs (lncRNAs) in multiple malignancies, including CC. Our study aimed to explore the role of lncRNA double homeobox A pseudogene 8 (DUXAP8) in cervical carcinogenesis. Methods Gene expressions in CC were assessed by RT-qPCR. Function experiments and tube formation assays were performed to evaluate the role of DUXAP8 in CC cells. Subcellular fractionation and FISH assays were conducted to determine the subcellular location of DUXAP8. Luciferase reporter, RNA pull down and RIP assays were conducted to investigate the mechanism of DUXAP8. Results DUXAP8 was notably upregulated in CC cells. Downregulation of DUXAP8 repressed cell malignant behaviors and angiogenesis in CC. Mechanically, DUXAP8 boosted the expression of reticulocalbin-2 (RCN2) through relieving the binding of miR-1297 to RCN2 3’-UTR. Moreover, miR-1297 inhibition and RCN2 overexpression could counteract the inhibitory effects of DUXAP8 knockdown on the malignant phenotypes of CC cells. Besides, enhanced RCN2 expression restored the tumor growth in vivo that was inhibited by DUXAP8 repression. Conclusions DUXAP8 promotes malignant behaviors in CC cells via regulating miR-1297/RCN2 axis. Graphical Abstract

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Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Cited by 187 publications

References 275 publications

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies

Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297

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