Regulation of Nutritional Metabolism in Transition Dairy Goats: Energy Balance, Liver Activity, and Insulin Resistance in Response to Berberine Supplementation

Ghavipanje, Navid; Nasri, M.H. Fathi; Farhangfar, Seyyed Homayoun; Ghiasi, Seyyed Ehsan; Vargas‐Bello‐Pérez, Einar

doi:10.3390/ani11082236

Cited by 11 publications

(20 citation statements)

References 65 publications

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“…In agreement with current findings, our recent report using the same animal cohort [21] revealed that BBR ingestion in transition goats enhanced pre-and post-partum intakes of DM and NEL. Likewise, it has been reported that BBR enhances energy homeostasis via AMP-activated protein kinase (AMPK) activation [16,[38][39][40].…”

Section: Dry Matter Intake Body Condition Score and Energy Balancesupporting

confidence: 93%

“…This article is part of a larger study that evaluated the effects of BBR supplementing on performance, glucose metabolism, insulin sensitivity, inflammation, and oxidative stress status in periparturient dairy goats. Our companion paper [21] revealed that BBR ameliorates the NEB in transition goats. The objective of the preset study was to reassess BBR supplementation as a novel preventive approach towards boosting antioxidant indicators in blood and milk, as well as its effects on FA profile in the colostrum and milk of goats during the transition period.…”

Section: Introductionmentioning

confidence: 87%

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The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats

Ghavipanje

Nasri

Farhangfar

et al. 2022

Veterinary Sciences

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The objective of this study was to investigate the effect of berberine (BBR) supplementation on productivity, antioxidant markers, and the fatty acid (FA) profile in the colostrum and milk of goats. Twenty-four primiparous Saanen goats were supplemented with 0, 1, 2, and 4 g/d (per goat) of BBR in control (CON), BBR1, BBR2, and BBR4 groups (n = 6 per group), respectively, from 21 days before expected kidding to 21 days after parturition. Blood sampling was carried out at −21, −14, −7, 0, 7, 14, and 21 d relative to delivery. Colostrum was collected within the first and second milking (d 1 of lactation), and milk was harvested weekly after kidding. Both BBR2 and BBR4 increased dry matter intake (DMI) (p ≤ 0.05) and energy balance (EB) as well as colostrum and milk production. Both BBR2 and BBR4 decreased (p ≤ 0.05) plasma levels of cholesterol, haptoglobin, and ceruloplasmin, while elevating the plasma albumin and paraoxonase (p ≤ 0.05), which may indicate that BBR mitigates inflammation during the transition period. BBR reduced (p ≤ 0.05) malondialdehyde (MDA) and increased (p ≤ 0.05) total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in blood, colostrum, and milk. Concentrations of de novo fatty acid in colostrum and milk were increased (p ≤ 0.05) with both BBR2 and BBR4. Free fatty acid (FFA) concentration in colostrum and milk fat were lower (p ≤ 0.05) in BBR2 and BBR4 compared to CON. The concentration of saturated fatty acids (SFAs) in colostrum and milk fat increased (p ≤ 0.05) with BBR2 and BBR4, while unsaturated fatty acids (USFAs) decreased (p ≤ 0.05) in milk. In summary, supplementation with at least 2 g/d BBR may enhance the EB and antioxidant status of dairy goats.

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Section: Dry Matter Intake Body Condition Score and Energy Balancesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 87%

The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats

Ghavipanje

Nasri

Farhangfar

et al. 2022

Veterinary Sciences

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“…Taken together, the aim of the present study was to determine the effect of BBR supplementation on glucose metabolism and somatotropic axis in dairy goats during late gestation and early lactation. Previous findings within this project confirmed that the BBR-fed does showed improvement in the energy balance (EB) around preparturition period [ 18 ]. Therefore, the hypothesis of this study was that BBR ingestion during the transition from late pregnancy to early lactation, affects glucose metabolism and IR as well as the somatotropic axis.…”

Section: Introductionsupporting

confidence: 77%

“…In a companion study, we observed that BBR supplementation led to reduction in body fat reserve mobilization as indicated by the lower NEFA and BHBA circulation as well as enhanced energy balance (EB) with faster recovery during the first 3 wk. PP [ 18 ]. Therefore, the central aim of present study was to clarify whether the favorable EB of BBR-supplemented dairy goats during transition state was related to enhancement of the regulation in somatotropic axis and glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

Berberine supplementation modulates the somatotropic axis and ameliorates glucose tolerance in dairy goats during late gestation and early lactation

et al. 2022

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Background Pregnancy, parturition, and the onset of lactation represent an enormous physiological and hormonal challenge to the homeostasis of dairy animals, being a risk for their health and reproduction. Thus, as a part of the homothetic changes in preparturition period, goats undergo a period of IR as well as uncoupled GH/IGF-1 axis. The objective for this study was to determine the effect of berberine (BBR) during the peripartal period on hormonal alteration and somatotropic axis in dairy goats as well as glucose and insulin kinetics during an intravenous glucose tolerance test (IVGTT). At 21 days before the expected kidding date, 24 primiparous Saanen goats were assigned randomly to 4 dietary treatments. Goats were fed a basal diet from wk. 3 antepartum (AP) until wk. 3 postpartum (PP) supplemented with 0 (CTRL), 1 (BBR1), 2 (BBR2), and 4 (BBR4) g/d BBR. Blood samples were collected on days − 21, − 14, − 7, 0, 7, 14, and 21 relative to the expected kidding date. An IVGTT was also performed on day 22 PP. Results Compared with CTRL, supplementation with either BBR2 or BBR4 increased DMI at kidding day and PP, as well as body conditional score (BCS) and milk production (p ≤ 0.05). On d 7 and 14 PP plasma glucose was higher in BBR2- and BBR4-treated than in CTRL. The glucagon concentration was not affected by BBR during the experimental period. However, supplemental BBR indicated a tendency to decrease in cortisol concentration on days 7 (p = 0.093) and 14 (p = 0.100) PP. Lower plasma GH was observed in BBR than in non-BBR goats (p ≤ 0.05). Plasma IGF-1 concentration was enhanced in both BBR2 and BBR4 at kidding and day 7 PP (p ≤ 0.05). During the IVGTT, glucose area under the curve (AUC), clearance rate (CR), T1/2, and Tbasal was lower (p ≤ 0.05) in both BBR2 and BBR4 goats as compared with CTRL. Likewise, the insulin CR was higher (p ≤ 0.05) in goats receiving either BBR2 or BBR4 which was accompanied by a lower insulin T1/2 and AUC. Conclusions Altogether, our results indicated an improved glucose and insulin status along with the modulation of the somatotropic axis and glucose and insulin response to IVGTT in dairy goats supplemented with 2 and 4 g/d BBR.

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“…The lower NEFA concentration in BBR2-and BBR4-fed goats may relate to BBR effects on improvement of energy status and reduction of body reserve usage. Likely, our previous finding (39) suggests that BBR may suppress lipolysis through enhancing feed intake and the endocrine responses that follow in periparturient dairy goats. In support of our findings, Shi et al (41) showed that BBR can improve NEFA-induced lipid accumulation in a dose-dependent manner in bovine hepatocytes.…”

Section: Biomarkers Of Energy Metabolismsupporting

confidence: 56%

Pre- and Post-partum Berberine Supplementation in Dairy Goats as a Novel Strategy to Mitigate Oxidative Stress and Inflammation

et al. 2021

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As in dairy cattle, goats during the transition period face risk factors, in particular negative energy balance (NEB), inflammation, and impairment of the antioxidant response. The current study determined the effects of pre- and post-partum berberine (BBR) supplementation on antioxidant status and inflammation response during the transition period in dairy goats. Twenty-four primiparous Saanen goats were randomly divided into four groups: control (CON, without BBR) and supplemented with 1 g/day BBR (BBR1), 2 g/day BBR (BBR2), or 4 g/day BBR (BBR4). The blood samples were collected weekly from 21 days pre-partum to 21 days post-partum. Compared with CON, supplementation with either BBR2 or BBR4 decreased (P ≤ 0.05) the levels of plasma non-esterified fatty acids (NEFA) at kidding and thereafter an increased (P ≤ 0.05) the plasma levels of glucose and insulin. Following BBR ingestion, blood antioxidant status elevated throughout the transition period, so that total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase activity were increased (P ≤ 0.05) and plasma malondialdehyde (MDA) was decreased (P ≤ 0.05). Likewise, paraoxonase (PON) was reduced (P ≤ 0.05) in goats fed BBR2 and BBR4. The levels of haptoglobin, ceruloplasmin, and bilirubin were reduced (P ≤ 0.05) by BBR2 and BBR4 immediately before kidding and thereafter. The results demonstrated that supplementation of either 2 or 4 g/day BBR enhanced antioxidant capacity and immune function of transition goats and improved post-partum performance showing its beneficial effect to mitigate oxidative stress and inflammation during the transition period in dairy goats.

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Regulation of Nutritional Metabolism in Transition Dairy Goats: Energy Balance, Liver Activity, and Insulin Resistance in Response to Berberine Supplementation

Cited by 11 publications

References 65 publications

The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats

The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats

Berberine supplementation modulates the somatotropic axis and ameliorates glucose tolerance in dairy goats during late gestation and early lactation

Pre- and Post-partum Berberine Supplementation in Dairy Goats as a Novel Strategy to Mitigate Oxidative Stress and Inflammation

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