Regulation of oocyte maturation: Role of conserved ERK signaling

Das, Debabrata; Arur, Swathi

doi:10.1002/mrd.23637

Cited by 17 publications

(6 citation statements)

References 244 publications

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“…The activation of CDK-1 counteracts the repression of CDK-1 by the Myt1 ortholog WEE-1.3 in oocytes, which inhibits the initiation of maturation [Yoon et al, 2012]. For a detailed review of ERK signalling in oogenesis, see Das and Arur [2022].…”

Section: Regulation Of Oocyte Meiotic Maturationmentioning

confidence: 99%

Oogenesis in Caenorhabditis elegans

Davis,

Hipwell,

Boag

2023

Sex Dev

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Background: The nematode, Caenorhabditis elegans has proven itself as a valuable model for investigating metazoan biology. C. elegans have a transparent body, an invariant cell lineage, and a high level of genetic conservation which makes it a desirable model organism. Although used to elucidate many aspects of somatic biology, a distinct advantage of C. elegans is its well annotated germline which allows all aspects of oogenesis to be observed in real time within a single animal. C. elegans hermaphrodites have two U-shaped gonad arms which produce their own sperm that is later stored to fertilise their own oocytes. These two germlines take up much of the internal space of each animal and germ cells are therefore the most abundant cell present within each animal. This feature and the genetic phenotypes observed for mutant worm gonads have allowed many novel findings that established our early understanding of germ cell dynamics. The mutant phenotypes also allowed key features of meiosis and germ cell maturation to be unveiled. Summary: This review will focus on the key aspects that make C. elegans an outstanding model for exploring each feature of oogenesis. This will include the fundamental steps associated with germline function and germ cell maturation and will be of use for those interested in exploring reproductive metazoan biology. Key Messages: Since germ cell biology is highly conserved in animals, much can be gained from study of a simple metazoan like C. elegans. Past findings have enhanced understanding on topics that would be more laborious or challenging in more complex animal models.

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Section: Regulation Of Oocyte Meiotic Maturationmentioning

confidence: 99%

Oogenesis in Caenorhabditis elegans

Davis,

Hipwell,

Boag

2023

Sex Dev

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“…Egg activation, representing the oocyte-to-embryo transition, is triggered by a calcium wave propagating within the oocytes [5]. Oogenesis, culminating in the formation of mature oocytes arrested at a specific meiotic stage, is controlled by numerous systemic regulatory inputs, including nutrition and hormonal signals [6][7][8]. The specific stage of meiosis arrest and its release upon egg activation depends on the animal species.…”

Section: Introductionmentioning

confidence: 99%

A fatty acid anabolic pathway in specialized-cells sustains a remote signal that controls egg activation in Drosophila

Poidevin,

Mazuras,

Bontonou

et al. 2024

PLoS Genet

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Egg activation, representing the critical oocyte-to-embryo transition, provokes meiosis completion, modification of the vitelline membrane to prevent polyspermy, and translation of maternally provided mRNAs. This transition is triggered by a calcium signal induced by spermatozoon fertilization in most animal species, but not in insects. In Drosophila melanogaster, mature oocytes remain arrested at metaphase-I of meiosis and the calcium-dependent activation occurs while the oocyte moves through the genital tract. Here, we discovered that the oenocytes of fruitfly females are required for egg activation. Oenocytes, cells specialized in lipid-metabolism, are located beneath the abdominal cuticle. In adult flies, they synthesize the fatty acids (FAs) that are the precursors of cuticular hydrocarbons (CHCs), including pheromones. The oenocyte-targeted knockdown of a set of FA-anabolic enzymes, involved in very-long-chain fatty acid (VLCFA) synthesis, leads to a defect in egg activation. Given that some but not all of the identified enzymes are required for CHC/pheromone biogenesis, this putative VLCFA-dependent remote control may rely on an as-yet unidentified CHC or may function in parallel to CHC biogenesis. Additionally, we discovered that the most posterior ventral oenocyte cluster is in close proximity to the uterus. Since oocytes dissected from females deficient in this FA-anabolic pathway can be activated in vitro, this regulatory loop likely operates upstream of the calcium trigger. To our knowledge, our findings provide the first evidence that a physiological extra-genital signal remotely controls egg activation. Moreover, our study highlights a potential metabolic link between pheromone-mediated partner recognition and egg activation.

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“…The LH receptor (LHR) is expressed on a subset of the outer granulosa cells, as well as some theca cells (Baena et al, 2020;Bortolussi et al, 1977;Bortolussi et al, 1979;Eppig et al, 2002;Peng et al, 1991;Richards et al, 1976;Uilenbroek and Richards, 1979). Binding of LH to its receptor induces meiotic resumption in the oocyte and changes in gene expression in the granulosa cells, via a G-protein-coupled signaling cascade (Das and Arur, 2022;Duffy et al, 2019;Hughes and Murphy, 2021;Jaffe and Egbert, 2017;Liu et al, 2014;Richards and Ascoli, 2018;Sposini and Hanyaloglu, 2018).…”

Section: Introductionmentioning

confidence: 99%

Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle

Owen

Jaffe

2023

Preprint

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Luteinizing hormone (LH) induces ovulation by initiating signaling by the mural granulosa cells that surround a mammalian oocyte in an ovarian follicle. However, much remains unknown about how LH activation of its receptor (LHR) modifies the structure of the follicle such that the oocyte is released and the follicle remnants are transformed into the corpus luteum. The present study shows that the preovulatory surge of LH stimulates LHR-expressing granulosa cells, initially located almost entirely in the outer layers of the mural granulosa, to rapidly extend inwards, intercalating between other cells. The proportion of LHR-expressing cell bodies in the inner half of the mural wall increases until the time of ovulation, with no change in the total number of cells expressing the receptor. Many of the initially flask-shaped cells appear to detach from the basal lamina, acquiring a rounder shape with multiple filipodia. Following the ingression of the LHR-expressing cells, but still hours before ovulation, the follicular wall develops numerous invaginations and constrictions. LH stimulation of granulosa cell ingression may contribute to changes in the follicular structure that enable ovulation.

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Regulation of oocyte maturation: Role of conserved ERK signaling

Cited by 17 publications

References 244 publications

Oogenesis in Caenorhabditis elegans

Oogenesis in Caenorhabditis elegans

A fatty acid anabolic pathway in specialized-cells sustains a remote signal that controls egg activation in Drosophila

Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle

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