Regulation of Oxidative Stress by Nitric Oxide Defines Lung Development and Diseases

Giri, Suvendu; Thakar, Sumukh; Majumder, Syamantak; Chatterjee, Suvro

doi:10.1007/978-981-32-9366-3_20

Cited by 1 publication

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“…At the same time, overexpression of exogenous NO levels in chicken embryos may increase the cell migration and cell proliferation on the right-hand side of the heart resulting in the situs inversus which is referred to as a congenital condition comprising of the reversion of the major visceral organs from their normal positions [ 16 ]. Recently, regulation of nitrosative and oxidative stresses by NO and its influence on lung diseases and cardiogenesis were thoroughly reviewed [ 17 , 18 ]. No wonder, the discovery of such crucial and indispensable biochemical patterns of NO stimulated a search of prodrug candidates capable of NO release under physiological conditions [ 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors

Ферштат

Zhilin

2021

Molecules

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Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.

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