Regulation of oxygen affinity in blood of fetal, newborn and adult mouse

Petschow, R.; Petschow, D.; Bartels, R.; Baumann, Rosemarie; Bartels, H.

doi:10.1016/0034-5687(78)90003-8

Cited by 41 publications

(13 citation statements)

References 17 publications

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“…For example, mouse Hb has a lower affinity for oxygen (P 50 ϭ 40 mm Hg) than human Hb (P 50 ϭ 25 mm Hg). 15 The P 50 of Hb has not been characterized in the sickle mouse model that we studied, though another transgenic sickle mouse model has an oxygen affinity that is slightly higher than that of normal mice but lower than human Hb (P 50 ϭ 33.5-37.4 mm Hg). 16 Thus, in our chimeric mice, unpolymerized human HbS may "steal" oxygen from normal mouse Hb under hypoxic conditions.…”

Section: Discussionmentioning

confidence: 91%

Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Iannone

Luznik

Engstrom

et al. 2001

Blood

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Sickle cell anemia (SCA) is an inherited disorder of ␤-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is associated with an 8% to 10% mortality rate, primarily from complications of marrowablative conditioning. Transplantation of allogeneic marrow after less intensive conditioning reduces toxicity but may result in stable mixed hematopoietic chimerism. The few SCA patients who inadvertently developed mixed chimerism after BMT remain symptom free, suggesting that mixed chimerism can reduce diseaserelated morbidity. However, because the effects of various levels of mixed chimerism on organ pathology have not been characterized, this study examined the histologic effects of an increasing percentage of normal donor hematopoiesis in a mouse model of BMT for SCA. In lethally irradiated normal mice that were reconstituted with varying ratios of T-celldepleted marrow from normal and transgenic "sickle cell" mice, normal myeloid chimerism in excess of 25% was associated with more than 90% normal hemoglobin (Hb). However, 70% normal myeloid chimerism was required to reverse the anemia. Organ pathology, including liver infarction, was present in mice with sickle Hb (HbS) levels as low as 16.8% (19.6% normal myeloid chimerism). Histologic abnormalities increased in severity up to 80% HbS, but were less severe in mice with more than 80% HbS than in those with 40% to 80% HbS. Therefore, stable mixed chimerism resulting from nonmyeloablative BMT may reduce the morbidity from SCA, but prevention of all disease complications may require minimizing the fraction of circulating sickle red cells. (Blood. 2001;97:3960-3965)

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Section: Discussionmentioning

confidence: 91%

Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Iannone

Luznik

Engstrom

et al. 2001

Blood

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“…The number and nature of layers between fetal and maternal blood flow bear no relationship to the ability of placentae to provide oxygen to the fetus , although this does not preclude differences in how oxygen is exchanged. The advantage to the embryo of haemochorial placentation, compared to epitheliochorial placentation, is direct access to the maternal blood: by placing the surface of the trophoblast in contact with maternal blood, the transport of glucose, amino acids, and inorganic ions are facilitated (Jelkmann and Bauer 1977;Petschow et al 1978;Franzke and Jelkmann 1982;Martin 2003;Vogel 2005;Kriegs et al 2006). In epitheliochorial placentae, transfer of nutrients such as iron and lipids is enhanced by the conspicuous development of the uterine glands, which typically occur in clusters adjacent to specially developed absorptive areas of the chorion.…”

Section: Diffusion and Exchangementioning

confidence: 98%

Life-History Correlates of Placental Structure in Eutherian Evolution

Lewitus

Soligo

2011

Evol Biol

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The eutherian placenta shows remarkable evolutionary plasticity. To date, however, success in identifying selection pressures behind the observed diversity of placental structures has been limited. Evolutionary convergence among definitive placental morphologies and between placental morphologies and life-history variables can be used to suggest functions of derived aspects of placentation. In this paper, we use, for the first time, a comprehensive phylogenetic comparative approach to map phenotypic character states of both placental morphologies and life-history characteristics of species onto hypotheses of phylogenetic relationships in Eutheria. We employ phylogenetic methods for ancestral reconstruction, mutational mapping, and association analysis to resolve associations between five aspects of placental structure and to identify dominant combinations, or syndromes, of placental morphology. We map twenty life-history characters onto the eutherian phylogeny to examine how they correlate, over evolutionary time, with the multivariate diversification of placental structures. We identify two distinct eutherian constellations, based on associations between life-history and placental structure, which broadly reflect a dichotomy between slow and fast life-history strategies. In addition, we suggest that the observed association between placental invasiveness and group size is indicative of the effect of social behavior on the utility of genomicimprinting in eutherian evolution.

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“…Changes in pH and the concentration of the allosteric effector 2,3-bisphosphoglycerate do not appear to have a significant effect on the P50 value of component El. Petschow et al (1978) report very low concentrations of 2,3-bisphosphoglycerate in mouse embryonic erythrocytes, and it is likely that at the earliest stages of gestation sensitivity of a haemoglobin to 2,3-bisphosphoglycerate would not be of any advantage, as the system controlling the production of this organic phosphate might not yet be fully operational and the quantities of 2,3-bisphosphoglycerate present would be negligible. The otherwise low release of°2 to the tissue at the earliest stages of development may be to some extent alleviated by the unusually high haemoglobin concentration within the developing embryo.…”

Section: Discussionmentioning

confidence: 99%

Molecular aspects of embryonic mouse haemoglobin ontogeny

Purdie¹,

Wells²,

Brittain³

1983

Biochemical Journal

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Embryos from C57BL/6J mice between the gestational ages of 9 and 16 days possess three embryonic haemoglobins EI, EII and EIII, the proportions of which change as a function of gestational age. Component EIj originally present at approx. 65% at day 9, decreases to approx. 20% by day 16 We now report on studies of the developmental pattern of embryonic haemoglobin production in a pure strain of mice (C57BL/6J). The component haemoglobins have been isolated and quantified during early development. An analysis of the 02-binding parameters for each of the isolated components has allowed us to simulate mathematically the anomalous 02-binding curves of the whole-blood system in terms of the contributions of each of the embryonic components. The properties of the individual components and their relative contributions to the whole embryonic erythrocyte system have been rationalized on the basis of the changing physiological demands for°2 encountered by the embryo in its changing intra-uterine environment. Materials and methodsMice of the strain C57BL/6J were obtained from the Animal Laboratory of the Cancer Society of New Zealand and housed under normal conditions. Timed matings were secured by the usual methods (Whitten, 1958). Pregnant female mice were killed and embryos dissected in cold saline solution (0.9% NaCl) as quickly as possible. For embryos of gestational age greater than 11 days it was possible to separate the umbilical blood vessels from the placenta and obtain blood by capillary sampling. Where appropriate, the erythrocytes were separated Vol. 215

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Regulation of oxygen affinity in blood of fetal, newborn and adult mouse

Cited by 41 publications

References 17 publications

Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Life-History Correlates of Placental Structure in Eutherian Evolution

Molecular aspects of embryonic mouse haemoglobin ontogeny

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